ArticleMolecular ecology resources2021
A chromosome-scale reference genome and genome-wide genetic variations elucidate adaptation in yak.
Article in Molecular ecology resources, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 37 citations in OpenAlex.
- Whole-genome resequencing data of 200 domestic yaks from China.Scientific data · 2026Article
- Divergent Amplification of Y-Linked Dosage-Sensitive Genes Triggers Regulatory Mismatch Underlying Cattle-Yak Male Sterility.Biomolecules · 2026Article
- Exploring Genomic Variability in the Mediterranean Buffalo Breed: A Step Towards Custom SNP Array.Animals : an open access journal from MDPI · 2026Article
- The role of lncRNA-associated ceRNA networks in yak longissimus dorsi muscle development across feeding systems.BMC veterinary research · 2026Article
- Effect of altitudes on serum parameters, metabolome, and gut microbiota in yaks on the Qinghai-Tibet Plateau.Microbiology spectrum · 2026Article
- Whole-genome resequencing reveals genomic characteristics and candidate genomic regions potentially associated with local adaptation of Leiwuqi yak (Frontiers in veterinary science · 2026Article
- Article
- Large-scale genome sequencing reveals population separation and selection signatures in major canyon yaks.BMC genomics · 2025Article
- Genetic Diversity Estimation and Genome-Wide Selective Sweep Analysis of the Bazhou Yak.Animals : an open access journal from MDPI · 2025Article
- Whole-genome resequencing revealed the genetic diversity and body weight-related genes of Gannan yak.Frontiers in veterinary science · 2025Article
- Viral metagenomic analysis of fecal samples fromFrontiers in cellular and infection microbiology · 2025Article
- Chromosome-level genome assembly and characterization of the Calophaca sinica genome.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- Pangenome and multi-tissue gene atlas provide new insights into the domestication and highland adaptation of yaks.Journal of animal science and biotechnology · 2024Article
- Yak genome database: a multi-omics analysis platform.BMC genomics · 2024Article
- Whole-genome resequencing reveals genetic diversity, differentiation, and selection signatures of yak breeds/populations in southwestern China.Frontiers in genetics · 2024Article
- Genome Variation Map of Domestic Qinghai-Tibet Plateau Yaks by SLAF-Seq Reveals Genetic Footprint during Artificial Selection.Animals : an open access journal from MDPI · 2023Article
- Whole-Genome Resequencing Highlights the Unique Characteristics of Kecai Yaks.Animals : an open access journal from MDPI · 2022Article
- Long read genome assemblies complemented by single cell RNA-sequencing reveal genetic and cellular mechanisms underlying the adaptive evolution of yak.Nature communications · 2022Article
- Article
- Genome-Wide Association Study of Body Weight Trait in Yaks.Animals : an open access journal from MDPI · 2022Article
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
Yak is an important livestock animal for the people indigenous to the harsh, oxygen-limited Qinghai-Tibetan Plateau and Hindu Kush ranges of the Himalayas. The yak genome was sequenced in 2012, but its assembly was fragmented because of the inherent limitations of the Illumina sequencing technology used to analyse it. An accurate and complete reference genome is essential for the study of genetic variations in this species. Long-read sequences are more complete than their short-read counterparts and have been successfully applied towards high-quality genome assembly for various species. In this study, we present a high-quality chromosome-scale yak genome assembly (BosGru_PB_v1.0) constructed with long-read sequencing and chromatin interaction technologies. Compared to an existing yak genome assembly (BosGru_v2.0), BosGru_PB_v1.0 shows substantially improved chromosome sequence continuity, reduced repetitive structure ambiguity, and gene model completeness. To characterize genetic variation in yak, we generated de novo genome assemblies based on Illumina short reads for seven recognized domestic yak breeds in Tibet and Sichuan and one wild yak from Hoh Xil. We compared these eight assemblies to the BosGru_PB_v1.0 genome, obtained a comprehensive map of yak genetic diversity at the whole-genome level, and identified several protein-coding genes absent from the BosGru_PB_v1.0 assembly. Despite the genetic bottleneck experienced by wild yak, their diversity was nonetheless higher than that of domestic yak. Here, we identified breed-specific sequences and genes by whole-genome alignment, which may facilitate yak breed identification.
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