Evidence map›Paper›PMID 32744455›Full record

ArticleBiotechnic & histochemistry : official publication of the Biological Stain Commission2021

The neutral red assay can be used to evaluate cell viability during autophagy or in an acidic microenvironment in vitro.

Jorge G Gomez-Gutierrez, Neal Bhutiani, Molly W McNally, Phillip Chuong, Wenyuan Yin, Meredith A Jones, Matthew R Zeiderman, William E Grizzle, Lacey R McNally

Open access · greenAbstract read
In one paragraph

Article in Biotechnic & histochemistry : official publication of the Biological Stain Commission, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. ACS omega · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Nanoparticles for cancer therapy: a review of influencing factors and evaluation methods for biosafety.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jorge G Gomez-GutierrezDepartment of Surgery, University of Louisville, Louisville, Kentucky.
Neal BhutianiDepartment of Surgery, University of Louisville, Louisville, Kentucky.
Molly W McNallyDepartment of Surgery, University of Oklahoma, Oklahoma City, Oklahoma.
Phillip ChuongDepartment of Surgery, University of Louisville, Louisville, Kentucky.
Wenyuan YinDepartment of Surgery, University of Louisville, Louisville, Kentucky.
Meredith A JonesSchool of Engineering, University of Oklahoma, Norman, Oklahoma.
Matthew R ZeidermanDepartment of Surgery, University of Louisville, Louisville, Kentucky.
William E GrizzleDepartment of Pathology, University of Alabama Birmingham, Birmingham, Alabama.
Lacey R McNallyDepartment of Surgery, University of Oklahoma, Oklahoma City, Oklahoma.
University of Louisville · USUniversity of Oklahoma · USUniversity of Alabama at Birmingham · US

Funding

University of Louisville Cancer Education ProgramR25CA134283 · NCI · UNIVERSITY OF LOUISVILLE · PI HEIN, DAVID W, KIDD, LA CREIS RENEE · 2011 to 2022
$3.1M
Stroma Targeted Theranostic Nanoparticles for Pancreatic CancerR01CA212350 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCNALLY, LACEY R · 2017 to 2021
$1.7M
Non-Invasive Detection of Tumor Extracellular pH using Multispectral Optoacoustic TomographyR01CA205941 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCNALLY, LACEY R · 2016 to 2021
$1.7M
Theranostic Nanoparticles For Detection and Treatment of Pancreatic CancerR01EB020125 · NIBIB · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCNALLY, LACEY R · 2016 to 2019
$1.7M
NCI NIH HHS R01 CA205941NCI NIH HHS R01 CA212350NCI NIH HHS R25 CA134283NIBIB NIH HHS R01 EB020125
6 · The paper itself

Abstract

Harsh conditions within the tumor microenvironment, such as hypoxia and extracellular acidic pH (pH

Indexed as

AutophagyAntineoplastic AgentsApoptosisCell Line, TumorCell SurvivalHumansNeutral RedAntineoplastic AgentsNeutral RedCell viabilitycytotoxicityextracellular acidic pHneutral redovarian cancerpancreatic cancer

Identifiers

PMID32744455
PMCPMC7861123
OpenAlexW3047551104

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.