ArticlePlant biotechnology journal2021
The wheat Sr22, Sr33, Sr35 and Sr45 genes confer resistance against stem rust in barley.
Article in Plant biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Introgressed Variation in TaMYB7-A1 Drives Graded Dormancy and Climate-Adaptive Pre-Harvest Sprouting Resistance in Wheat.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Unraveling plant immunity: from pathogen perception to resistance engineering.Science China. Life sciences · 2026Review
- Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Harnessing primary, secondary and tertiary genepools for durable wheat disease resistance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Discovery of functional NLRs using expression level, high-throughput transformation and large-scale phenotyping.Nature plants · 2025Article
- Article
- Genetic engineering, including genome editing, for enhancing broad-spectrum disease resistance in crops.Plant communications · 2025Review
- All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Speed breeding: protocols, application and achievements.Frontiers in plant science · 2025Review
- Uncovering the Mechanisms: The Role of Biotrophic Fungi in Activating or Suppressing Plant Defense Responses.Journal of fungi (Basel, Switzerland) · 2024Review
- Genetic Basis Identification of aInternational journal of molecular sciences · 2024Article
- Resistance that stacks up: engineering rust and mildew disease control in the cereal crops wheat and barley.Plant biotechnology journal · 2023Review
- Advances in the Mining of Disease Resistance Genes fromPlants (Basel, Switzerland) · 2023Review
- Engineering plant immune circuit: walking to the bright future with a novel toolbox.Plant biotechnology journal · 2023Review
- Identification of wheat stem rust resistance genes in wheat cultivars from Hebei province, China.Frontiers in plant science · 2023Article
- TRustDB: A comprehensive bioinformatics resource for understanding the complete Wheat-Stem rust host-pathogen interactome.Database : the journal of biological databases and curation · 2022Article
- Deciphering the Crosstalk Mechanisms of Wheat-Stem Rust Pathosystem: Genome-Scale Prediction Unravels Novel Host Targets.Frontiers in plant science · 2022Article
- A recombined Sr26 and Sr61 disease resistance gene stack in wheat encodes unrelated NLR genes.Nature communications · 2021Article
- The wheat Sr22, Sr33, Sr35 and Sr45 genes confer resistance against stem rust in barley.Plant biotechnology journal · 2021Article
- Fine mapping of leaf rust resistance gene Rph13 from wild barley.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
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Authors and funding
20 authors at 4 institutions in 4 countries.
Funding
Abstract
In the last 20 years, stem rust caused by the fungus Puccinia graminis f. sp. tritici (Pgt), has re-emerged as a major threat to wheat and barley production in Africa and Europe. In contrast to wheat with 60 designated stem rust (Sr) resistance genes, barley's genetic variation for stem rust resistance is very narrow with only ten resistance genes genetically identified. Of these, only one complex locus consisting of three genes is effective against TTKSK, a widely virulent Pgt race of the Ug99 tribe which emerged in Uganda in 1999 and has since spread to much of East Africa and parts of the Middle East. The objective of this study was to assess the functionality, in barley, of cloned wheat Sr genes effective against race TTKSK. Sr22, Sr33, Sr35 and Sr45 were transformed into barley cv. Golden Promise using Agrobacterium-mediated transformation. All four genes were found to confer effective stem rust resistance. The barley transgenics remained susceptible to the barley leaf rust pathogen Puccinia hordei, indicating that the resistance conferred by these wheat Sr genes was specific for Pgt. Furthermore, these transgenic plants did not display significant adverse agronomic effects in the absence of disease. Cloned Sr genes from wheat are therefore a potential source of resistance against wheat stem rust in barley.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.