Evidence map›Paper›PMID 32744243›Full record

ArticleActa crystallographica. Section F, Structural biology communications2020

Crystal structure of the FYCO1 RUN domain suggests possible interfaces with small GTPases.

Shunya Sakurai, Toshiyuki Shimizu, Umeharu Ohto

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta crystallographica. Section F, Structural biology communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Persistent Mayer Dirac.Journal of physics. Complexity · 2024
    Article
  2. Article
  3. Implications of AlphaFold2 for crystallographic phasing by molecular replacement.Acta crystallographica. Section D, Structural biology · 2022
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Shunya SakuraiGraduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Toshiyuki ShimizuGraduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Umeharu OhtoGraduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
The University of Tokyo · JP

Funding

Ministry of Education, Culture, Sports, Science and Technology 19H00976Ministry of Education, Culture, Sports, Science and Technology 26711002
6 · The paper itself

Abstract

FYCO1 is a multidomain adaptor protein that plays an important role in autophagy by mediating the kinesin-dependent microtubule plus-end-directed transport of autophagosomes. FYCO1 contains a RUN domain, which is hypothesized to function as a specific effector for members of the Ras superfamily of small GTPases, but its role has not been well characterized and its interaction partner(s) have not been identified. Here, the crystal structure of the FYCO1 RUN domain was determined at 1.3 Å resolution. The overall structure of the FYCO1 RUN domain was similar to those of previously reported RUN domains. Detailed structural comparisons with other RUN domains and docking studies suggested a possible interaction interface of the FYCO1 RUN domain with small GTPases of the Ras superfamily.

Indexed as

Adaptor Proteins, Signal TransducingAmino Acid SequenceAnimalsBinding SitesCarrier ProteinsCloning, MolecularCrystallography, X-RayCytoskeletal ProteinsEscherichia coliGene ExpressionGenetic VectorsGuanine Nucleotide Exchange FactorsHumansMicrotubule-Associated ProteinsMolecular Docking SimulationProtein BindingAdaptor Proteins, Signal TransducingCarrier ProteinsCytoskeletal ProteinsDENND5A protein, humanFYCO1 protein, humanGuanine Nucleotide Exchange FactorsMicrotubule-Associated ProteinsRecombinant ProteinsRUFY3 protein, humanRUSC1 protein, humanRUSC2 protein, humanautophagyFYCO1RUN domainsmall GTPase bindingX-ray crystallography

Identifiers

PMID32744243
PMCPMC7397462
OpenAlexW3046417859

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.