Evidence map›Paper›PMID 32744087›Full record

ArticleAmerican journal of physiology. Renal physiology2020

PF-06869206 is a selective inhibitor of renal P

Linto Thomas, Jianxiang Xue, Viktor N Tomilin, Oleh M Pochynyuk, Jessica A Dominguez Rieg, Timo Rieg

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Updates on renal phosphate transport.Current opinion in nephrology and hypertension · 2025
    Review
  5. Review
  6. Article
  7. Beyond SGLT2: proximal tubule transporters as potential drug targets for chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review
  8. Article
  9. Vitamin DScientific reports · 2024
    Article
  10. Pharmacology of Mammalian NaHandbook of experimental pharmacology · 2024
    Article
  11. Review
  12. Physiopathology of Phosphate Disorders.Advances in kidney disease and health · 2023
    Review
  13. Npt2a as a target for treating hyperphosphatemia.Biochemical Society transactions · 2022
    Review
  14. Article
  15. Kidney physiology: our future is now.American journal of physiology. Renal physiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Linto ThomasDepartment of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida.
Jianxiang XueDepartment of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida.
Viktor N TomilinDepartment of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, Texas.
Oleh M PochynyukDepartment of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, Texas.ORCID 0000-0002-5397-6897
Jessica A Dominguez RiegDepartment of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida.
Timo RiegDepartment of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida.ORCID 0000-0001-6082-662X
University of South Florida · USThe University of Texas Health Science Center at Houston · US

Funding

Physiology of ClC-K2/b Cl- channel in the collecting ductR01DK117865 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI POCHYNYUK, OLEH · 2019 to 2023
$1.7M
Regulation of K+ balance by distal nephron TRPV4 channelR01DK119170 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI POCHYNYUK, OLEH · 2018 to 2022
$1.7M
Role of Renal and Intestinal AC6 and NHE3 for Phosphate HomeostasisR01DK110621 · NIDDK · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI RIEG, TIMO · 2016 to 2020
$1.7M
Aldosterone-independent regulation of ENaC by systemic saltR01DK095029 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI POCHYNYUK, OLEH · 2012 to 2016
$1.6M
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK095029HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK117865HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK110621NIDDK NIH HHS R01 DK095029NIDDK NIH HHS R01 DK110621NIDDK NIH HHS R01 DK117865NIDDK NIH HHS R01 DK119170
6 · The paper itself

Abstract

Plasma phosphate (P

Indexed as

AnimalsBiological TransportCell LineGene Expression RegulationMiceMice, Inbred C57BLMice, KnockoutOpossumsParathyroid HormonePatch-Clamp TechniquesPhosphatesRandom AllocationSodium-Phosphate Cotransporter Proteins, Type IIaParathyroid HormonePhosphatesSlc34a1 protein, mouseSodium-Phosphate Cotransporter Proteins, Type IIachronic kidney diseaseinhibitorNpt2a knockoutopossum kidney cellsphosphate

Identifiers

PMID32744087
PMCPMC7509280
OpenAlexW3047441700

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.