Evidence map›Paper›PMID 32744078›Full record

ArticleExpert opinion on drug safety2020

Is the lack of evidence in older adults with cancer compromising safety?

Darryl Outlaw, Grant R Williams

Abstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in Expert opinion on drug safety, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Darryl OutlawDivision of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham , Birmingham, USA.
Grant R WilliamsDivision of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham , Birmingham, USA.

Funding

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults with Colorectal Cancer: The M&M StudyK08CA234225 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WILLIAMS, GRANT R · 2018 to 2022
$1.0M
NCI NIH HHS K08 CA234225
6 · The paper itself

Abstract

The number of older adults with cancer is increasing, and this group is forecasted to represent a larger portion of the field of oncology over the decades to come. Many unique challenges exist in the care of older adults with cancer, from age-related changes in physiology to the increased presence of comorbidities, polypharmacy, and geriatric syndromes. Unfortunately, there remains a significant knowledge gap in the optimal management of this growing population, as the majority of cancer research and clinical trials focus on younger, healthier patients, which consequently complicates the applicability of this work in the older adult population and potentially compromises safety. In this article, we further explore the challenges facing the field of geriatric oncology and discuss strategies to close the knowledge gap facing older adults with cancer.

Indexed as

AgedAge FactorsAgingGeriatric AssessmentHumansNeoplasmsPolypharmacyagingcancerevidence-based medicinefrailtyGeriatric oncologypolypharmacy

Identifiers

PMID32744078
PMCPMC7554204

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.