Evidence map›Paper›PMID 32743931›Full record

ArticleJournal of applied microbiology2021

Validation of the bag-mediated filtration system for environmental surveillance of poliovirus in Nairobi, Kenya.

C S Fagnant-Sperati, Y Ren, N A Zhou, E Komen, B Mwangi, J Hassan, A Chepkurui, R Nzunza, J Nyangao, W B van Zyl and 15 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Environmental surveillance of pathogens in Africa.Applied and environmental microbiology · 2026
    Review
  2. Review
  3. Article
  4. Wastewater Surveillance of SARS-CoV-2 in Zambia: An Early Warning Tool.International journal of molecular sciences · 2024
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 5 institutions in 3 countries.

C S Fagnant-SperatiDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.ORCID https://orcid.org/0000-0001-9794-307X
Y RenDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
N A ZhouDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.ORCID https://orcid.org/0000-0002-3854-376X
E KomenCentre for Viral Research, Kenya Medical Research Institute, Nairobi, Kenya.
B MwangiCentre for Viral Research, Kenya Medical Research Institute, Nairobi, Kenya.
J HassanCentre for Viral Research, Kenya Medical Research Institute, Nairobi, Kenya.
A ChepkuruiCentre for Viral Research, Kenya Medical Research Institute, Nairobi, Kenya.
R NzunzaCentre for Viral Research, Kenya Medical Research Institute, Nairobi, Kenya.
J NyangaoCentre for Viral Research, Kenya Medical Research Institute, Nairobi, Kenya.
W B van ZylDepartment of Medical Virology, University of Pretoria, Pretoria, South Africa.
M WolfaardtDepartment of Medical Virology, University of Pretoria, Pretoria, South Africa.
P N MatsapolaDepartment of Medical Virology, University of Pretoria, Pretoria, South Africa.
F B NgwanaDepartment of Medical Virology, University of Pretoria, Pretoria, South Africa.
S Jeffries-MilesCherokee Nation Assurance a contracting agency to the Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
A Coulliette-SalmondDivision of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
S PeñarandaDivision of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
E VegaDivision of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
J H ShiraiDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
A L KossikDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
N K BeckDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.
D S BoylePATH, Seattle, WA, USA.
C C BurnsDivision of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
M B TaylorDepartment of Medical Virology, University of Pretoria, Pretoria, South Africa.ORCID https://orcid.org/0000-0002-2780-5795
P BorusCentre for Viral Research, Kenya Medical Research Institute, Nairobi, Kenya.
J S MeschkeDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.ORCID https://orcid.org/0000-0002-8983-9042
Kenya Medical Research Institute · KEUniversity of Washington · USCenters for Disease Control and Prevention · USUniversity of Pretoria · ZAProgram for Appropriate Technology in Health · US

Funding

Biostatistics, Epidemiologic & Bioinformatic Training in Environmental HealthT32ES015459 · NIEHS · UNIVERSITY OF WASHINGTON · PI June T. Spector · 2009 to 2026
$10.6M
Bill and Melinda Gates Foundation OPP1170548NIEHS NIH HHS T32 ES015459NIEHS NIH HHS T32ES015459Paul G. Allen Family Foundation NPT.1938-603689
6 · The paper itself

Abstract

aimsThis study compared the bag-mediated filtration system (BMFS) and standard WHO two-phase separation methods for poliovirus (PV) environmental surveillance, examined factors impacting PV detection and monitored Sabin-like (SL) PV type 2 presence with withdrawal of oral polio vaccine type 2 (OPV2) in April 2016. METHODS AND

resultsEnvironmental samples were collected in Nairobi, Kenya (Sept 2015-Feb 2017), concentrated via BMFS and two-phase separation methods, then assayed using the WHO PV isolation algorithm and intratypic differentiation diagnostic screening kit. SL1, SL2 and SL3 were detected at higher rates in BMFS than two-phase samples (P < 0·05). In BMFS samples, SL PV detection did not significantly differ with volume filtered, filtration time or filter shipment time (P > 0·05), while SL3 was detected less frequently with higher shipment temperatures (P = 0·027). SL2 was detected more frequently before OPV2 withdrawal in BMFS and two-phase samples (P < 1 × 10

conclusionsPoliovirus was detected at higher rates with the BMFS, a method that includes a secondary concentration step, than using the standard WHO two-phase method. SL2 disappearance from the environment was commensurate with OPV2 withdrawal. SIGNIFICANCE AND IMPACT OF THE STUDY: The BMFS offers comparable or improved PV detection under the conditions in this study, relative to the two-phase method.

Indexed as

Environmental MonitoringFiltrationHumansKenyaPoliomyelitisPoliovirusPoliovirus Vaccine, OralSerogroupSewagePoliovirus Vaccine, OralSewageenteric virusesenvironmental surveillancefiltrationKenyapoliovirusViroCapwastewater

Identifiers

PMID32743931
PMCPMC7854911
OpenAlexW3046799344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.