Evidence map›Paper›PMID 32743873›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2021

Brain death-induced lung injury is complement dependent, with a primary role for the classical/lectin pathway.

Judith E van Zanden, Neeltina M Jager, Marc A Seelen, Mohamed R Daha, Zwanida J Veldhuis, Henri G D Leuvenink, Michiel E Erasmus

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Emerging roles for complement in lung transplantation.The Journal of clinical investigation · 2025
    Review
  2. Article
  3. Brain death-induced lung injury is complement dependent, with a primary role for the classical/lectin pathway.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Judith E van ZandenDepartment of Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0003-0095-2098
Neeltina M JagerDepartment of Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Marc A SeelenDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Mohamed R DahaDivision of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Zwanida J VeldhuisDepartment of Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Henri G D LeuveninkDepartment of Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Michiel E ErasmusDepartment of Cardiothoracic Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
University Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In brain-dead donors immunological activation occurs, which deteriorates donor lung quality. Whether the complement system is activated and which pathways are herein involved, remain unknown. We aimed to investigate whether brain death (BD)-induced lung injury is complement dependent and dissected the contribution of the complement activation pathways. BD was induced and sustained for 3 hours in wild-type (WT) and complement deficient mice. C3

Indexed as

Brain DeathLung InjuryAnimalsComplement ActivationInflammationLectinsMiceLectinsbasic (laboratory) research/sciencecomplement biologydonors and donation: donation after brain death (DBD)immunosuppression/immune modulationlung transplantation/pulmonologytranslational research/science

Identifiers

PMID32743873
PMCPMC7984080
OpenAlexW3047396818

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.