ReviewJournal of endocrinological investigation2021
Bone metastases from differentiated thyroid carcinoma: current knowledge and open issues.
Review in Journal of endocrinological investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Adding pieces to the puzzle of differentiated-to-anaplastic thyroid cancer evolution: the oncogene E2F7.Cell death & disease · 2023Pooled it
- Radiotherapy for the management of bone metastases in differentiated thyroid cancer.Clinical and translational radiation oncology · 2026Article
- Rare metastatic sites in three patients with RAI-refractory differentiated thyroid cancer (DTC).Hormones (Athens, Greece) · 2026Review
- Role of radiofrequency ablation in the treatment of symptomatic distant metastasis of thyroid cancer.Skeletal radiology · 2025Article
- Bilateral osteonecrosis of the external auditory canal caused by bone-modifying agents for cancer bone metastases.International cancer conference journal · 2025Article
- Article
- What Factors Are Associated With Implant Revision in the Treatment of Pathologic Subtrochanteric Femur Fractures?Clinical orthopaedics and related research · 2025Article
- Article
- Plasma exchange as a rescue therapy for treatment-resistant thyroid storm with concurrent heart failure: a literature review based on a case report.International journal of emergency medicine · 2024Article
- Impact of distant metastasis on overall survival and cancer specific survival of elderly patients with differentiated thyroid cancer.Scientific reports · 2024Article
- Differentiated thyroid carcinoma: what the nonspecialists needs to know.Archives of endocrinology and metabolism · 2024Review
- Retrospective Evaluation of Bone Metastases in Patients With Thyroid Malignancy: A Single-Center Experience.Cureus · 2024Article
- Case report: A case of hyperthyroidism secondary to bone metastasis of differentiated thyroid cancer.Frontiers in oncology · 2024Article
- Unusual metastasis of papillary thyroid carcinoma to the spine: A case report.Radiology case reports · 2023Article
- Calcaneus metastasis: a rare presentation of poorly differentiated thyroid cancer.Endocrinology, diabetes & metabolism case reports · 2023Article
- Osseous Metastases in Thyroid Cancer: Unveiling Risk Factors, Disease Outcomes, and Treatment Impact.Cancers · 2023Article
- Review
- Tenosynovial Giant Cell Tumor of Foot in a Patient with Radioiodine-Refractory Thyroid Cancer: Imaging Findings on FDG-PET/CT, MRI, and Radioiodine Scan.World journal of nuclear medicine · 2023Article
- Article
- Surgery for metastatic spinal differentiated thyroid cancer: feasibility, outcome, and prognostic factors.Frontiers in surgery · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone represents the second most common site of distant metastases in differentiated thyroid cancer (DTC). The clinical course of DTC patients with bone metastases (BM) is quite heterogeneous, but generally associated with low survival rates. Skeletal-related events might be a serious complication of BM, resulting in high morbidity and impaired quality of life. To achieve disease control and symptoms relief, multimodal treatment is generally required: radioiodine therapy, local procedures-including surgery, radiotherapy and percutaneous techniques-and systemic therapies, such as kinase inhibitors and antiresorptive drugs. The management of DTC with BM is challenging: a careful evaluation and a personalized approach are essential to improve patients' outcomes. To date, prospective studies focusing on the main clinical aspects of DTC with BM are scarce; available analyses mainly include cohorts assembled over multiple decades, small samples sizes and data about BM not always separated from those regarding other distant metastases. The aim of this review is to summarize the most recent evidences and the unsolved questions regarding BM in DTC, analyzing several key issues: pathophysiology, prognostic factors, role of anatomic and functional imaging, and clinical management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.