Evidence map›Paper›PMID 32743705›Full record

ArticleRheumatology international2020

Does immunosuppressive treatment entail an additional risk for children with rheumatic diseases? A survey-based study in the era of COVID-19.

Oya Koker, Fatma Gul Demirkan, Gulsah Kayaalp, Figen Cakmak, Ayse Tanatar, Serife Gul Karadag, Hafize Emine Sonmez, Rukiye Omeroglu, Nuray Aktay Ayaz

Abstract read
In one paragraph

Article in Rheumatology international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. COVID-19 in immunocompromised children and adolescents.Clinical and experimental pediatrics · 2023
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Optimal biologics for juvenile idiopathic arthritis in an infection with SARS-CoV-2 α-variant.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
    Article
  10. Impact of COVID-19 on Pediatric Immunocompromised Patients.Pediatric clinics of North America · 2021
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Observational
  18. Article
  19. COVID-19 in Immunosuppressed Children.Frontiers in pediatrics · 2021
    Review
  20. Reporting Survey Based Studies - a Primer for Authors.Journal of Korean medical science · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Oya KokerDepartment of Paediatric Rheumatology, Istanbul Faculty of Medical School, Istanbul University, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-0101-9585
Fatma Gul DemirkanDepartment of Paediatric Rheumatology, Istanbul Faculty of Medical School, Istanbul University, Istanbul, Turkey.ORCID http://orcid.org/0000-0001-9950-2489
Gulsah KayaalpDepartment of Paediatric Rheumatology, Istanbul Faculty of Medical School, Istanbul University, Istanbul, Turkey.ORCID http://orcid.org/0000-0001-7490-7076
Figen CakmakDepartment of Paediatric Rheumatology, Istanbul Faculty of Medical School, Istanbul University, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-1667-2480
Ayse TanatarDepartment of Paediatric Rheumatology, Istanbul Faculty of Medical School, Istanbul University, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-1386-4575
Serife Gul KaradagDepartment of Paediatric Rheumatology, Kanuni Sultan Süleyman Research and Training Hospital, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-3232-0055
Hafize Emine SonmezDepartment of Paediatric Rheumatology, Kanuni Sultan Süleyman Research and Training Hospital, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-9186-3068
Rukiye OmerogluDepartment of Paediatric Rheumatology, Istanbul Faculty of Medical School, Istanbul University, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-3740-6552
Nuray Aktay AyazDepartment of Paediatric Rheumatology, Istanbul Faculty of Medical School, Istanbul University, Istanbul, Turkey. nurayaktay@gmail.com.ORCID http://orcid.org/0000-0003-3594-7387

Funding

Bilimsel Araştirma Projeleri Birimi, Istanbul Üniversitesi 36852
6 · The paper itself

Abstract

The aim of the research was to further extend current knowledge of whether severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disease 2019 (COVID-19) entails a risk for children with various rheumatic diseases under immunosuppressive treatment. Telephone survey was administered by conducting interviews with the parents from May 1, 2020 to May 20, 2020. A message containing a link to the actual questionnaire was sent to their phones simultaneously. The medical records of the patients were reviewed for gathering information about demographic data, clinical follow-up, and treatments. Patients who were followed-up under immunosuppressive treatment (n = 439) were attempted to be contacted. The diagnostic distribution of patients (n = 414) eligible for the study was as follows: juvenile idiopathic arthritis (JIA) (n = 243, 58.7%), autoinflammatory diseases (n = 109, 26.3%), connective tissue diseases (n = 51, 12.3%), and vasculitis (n = 11, 2.7%). In the entire cohort, the mean age was 12 ± 4.7 years, and 54.1% (n = 224) were female. Nine patients have attended the hospital for COVID-19 evaluation, 6 of whom were in close contact with confirmed cases. One patient with seronegative polyarticular JIA, previously prescribed methotrexate and receiving leflunomide during pandemic was identified to be diagnosed with COVID-19. None, including the confirmed case, had any severe symptoms. More than half of the patients with household exposure did not require hospitalization as they were asymptomatic. Although circumstances such as compliance in social distancing policy, transmission patterns, attitude following contact may have influenced the results, immunosuppressive treatment does not seem to pose an additional risk in terms of COVID-19.

Indexed as

AdolescentArthritis, JuvenileBetacoronavirusChildConnective Tissue DiseasesCoronavirus InfectionsCOVID-19FemaleHereditary Autoinflammatory DiseasesHumansImmunosuppressive AgentsMalePandemicsPneumonia, ViralRisk FactorsSARS-CoV-2Immunosuppressive AgentsBiological therapiesCOVID-19DmardsImmunosuppressantsPaediatric rheumatology

Identifiers

PMID32743705
PMCPMC7395897

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.