Evidence map›Paper›PMID 32743565›Full record

ArticleResearch square2020

Severe SARS-CoV-2 infection in humans is defined by a shift in the serum lipidome resulting in dysregulation of eicosanoid immune mediators.

Benjamin Schwarz, Lokesh Sharma, Lydia Roberts, Xiaohua Peng, Santos Bermejo, Ian Leighton, Arnau Casanovas Massana, Shelli Farhadian, Albert I Ko, Yale IMPACT Team and 2 more

Abstract readPreprint
In one paragraph

Article in Research square, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Benjamin SchwarzLaboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Lokesh SharmaSection of Pulmonary and Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut.
Lydia RobertsLaboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Xiaohua PengSection of Pulmonary and Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut.
Santos BermejoSection of Pulmonary and Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut.
Ian LeightonLaboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Arnau Casanovas MassanaDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06520.
Shelli FarhadianDepartment of Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT, 06520.
Albert I KoDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06520.
Yale IMPACT Team
Charles S Dela CruzSection of Pulmonary and Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut.
Catharine M BosioLaboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Systems investigation of vaccine responses in B cell depleted autoimmune patientsU19AI089992 · NIAID · YALE UNIVERSITY · PI David A. Hafler, RUTH R MONTGOMERY · 2010 to 2026
$50.4M
MAVS-Mediated Pulmonary Inflammation and Injury Response During Cigarette Smoke Exposure and Influenza Viral Infection and in COPDI01BX004661 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI DELA CRUZ, CHARLES S · 2020 to 2024
–
BLRD VA I01 BX004661NCATS NIH HHS UL1 TR001863NIAID NIH HHS U19 AI089992
6 · The paper itself

Abstract

The COVID-19 pandemic has affected more than 10 million people worldwide with mortality exceeding half a million patients. Risk factors associated with severe disease and mortality include advanced age, hypertension, diabetes, and obesity.

Identifiers

PMID32743565
PMCPMC7386513

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.