Evidence map›Paper›PMID 32743529›Full record

ArticleJournal of translational autoimmunity2020

Antibody response to homologous epitopes of Epstein-Barr virus,

Marco Bo, Magdalena Niegowska, Hayley L Eames, Hannah Almuttaqi, Giannina Arru, Gian Luca Erre, Giuseppe Passiu, Tariq E Khoyratty, Erinke van Grinsven, Irina A Udalova and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational autoimmunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  13. Targeting AhR as a Novel Therapeutic Modality against Inflammatory Diseases.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Marco BoDepartment of Biomedical Sciences, Section of Microbiology and Virology, University of Sassari, Viale San Pietro 43b, 07100, Sassari, Italy.
Magdalena NiegowskaDepartment of Biomedical Sciences, Section of Microbiology and Virology, University of Sassari, Viale San Pietro 43b, 07100, Sassari, Italy.
Hayley L EamesKennedy Institute of Rheumatology, Oxford University, Oxford, Roosevelt Drive, Headington, OX3 7FY, United Kingdom.
Hannah AlmuttaqiKennedy Institute of Rheumatology, Oxford University, Oxford, Roosevelt Drive, Headington, OX3 7FY, United Kingdom.
Giannina ArruDepartment of Clinical, Surgical and Experimental Medicine, Neurological Clinic, University of Sassari, Viale San Pietro 8, 07100, Sassari, Italy.
Gian Luca ErreDepartment of Clinical and Experimental Medicine, Azienda Ospedaliero-Universitaria di Sassari, UOC of Rheumatology, Viale San Pietro 8, 07100, Sassari, Italy.
Giuseppe PassiuDepartment of Clinical and Experimental Medicine, Azienda Ospedaliero-Universitaria di Sassari, UOC of Rheumatology, Viale San Pietro 8, 07100, Sassari, Italy.
Tariq E KhoyrattyKennedy Institute of Rheumatology, Oxford University, Oxford, Roosevelt Drive, Headington, OX3 7FY, United Kingdom.
Erinke van GrinsvenKennedy Institute of Rheumatology, Oxford University, Oxford, Roosevelt Drive, Headington, OX3 7FY, United Kingdom.
Irina A UdalovaKennedy Institute of Rheumatology, Oxford University, Oxford, Roosevelt Drive, Headington, OX3 7FY, United Kingdom.
Leonardo A SechiDepartment of Biomedical Sciences, Section of Microbiology and Virology, University of Sassari, Viale San Pietro 43b, 07100, Sassari, Italy.
University of Oxford · GBUniversity of Sassari · ITAzienda Ospedaliero Universitaria di Sassari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImproved knowledge of different biomarkers is crucial for early diagnosis of rheumatic diseases and to provide important insights for clinical management. In this study, we evaluated the seroreactivity of patients with different connective tissue diseases (CTDs) (rheumatoid arthritis, RA; systemic lupus erythematosus, SLE; systemic sclerosis, SSc; and Sjogren's syndrome, SSj) to interferon regulatory factor 5 (IRF5) peptide and homologs derived from Epstein-Barr virus (EBV) and

methodsReactivity against wild-type (wt) and citrullinated (cit) IRF5 (IRF5

resultsBOLF1, MAP_4027 and IRF5 peptides triggered different antibody responses in CTD diseases with a stronger reactivity in RA (

Indexed as

CitrullinationEBVIRF5MAPMouse models of rheumatoid arthritisRheumatic diseases

Identifiers

PMID32743529
PMCPMC7388397
OpenAlexW3010826199

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.