ArticleAnnals of geriatric medicine and research2020
Anticholinergic Cognitive Burden as a Predictive Factor for In-hospital Mortality in Older Patients in Korea.
Article in Annals of geriatric medicine and research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Anticholinergic Burden at Admission and Discharge Among Geriatric Inpatients: A Single-Center Retrospective Cohort Study.International journal of general medicine · 2026Article
- Anticholinergic burden and its associated factors among adult outpatients in a resource-limited setting: a cross-sectional study.Scientific reports · 2025Article
- The assessment of the relationship between anticholinergic burden and short-term blood pressure variability.BMC pharmacology & toxicology · 2025Article
- Nonsteroidal anti-inflammatory drug use is associated with improved activities of daily living and rehabilitation in older adult patients following a fracture: a retrospective cohort study.Journal of pharmaceutical health care and sciences · 2025Article
- Comparison of anticholinergic burden with chronic polypharmacy on functional decline and mortality in Korean older people: a retrospective nationwide cohort study.BMC geriatrics · 2024Article
- Anticholinergic burden among in-patients: a cross-sectional study on prevalence, determinants, and impact on mortality in Ethiopia.Therapeutic advances in drug safety · 2024Article
- Potentially Inappropriate Medication Use among Nursing Home Residents: Medication Errors Associated with Pro re nata Medications and the Importance of Pill Burden.Annals of geriatric medicine and research · 2022Article
- A Descriptive Study of Emergency Department Visits Within 30 Days of Discharge.Annals of geriatric medicine and research · 2021Article
- Clinical Frailty Scale, K-FRAIL questionnaire, and clinical outcomes in an acute hospitalist unit in Korea.The Korean journal of internal medicine · 2021Article
- Clinical outcomes associated with anticholinergic burden in older hospitalized patients with advanced cancer: a single-center database study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith the increasing prevalence of chronic disease due to aging, many older adults experience multimorbidity and polypharmacy. Medications with anticholinergic properties are particularly associated with adverse cognitive outcomes, including functional decline and mortality. We assessed the clinical impact of anticholinergic cognitive burden (ACB) on clinical outcomes of older patients acutely admitted to a single, hospitalist-operated medical unit of a tertiary hospital in Korea.
methodsThis retrospective study reviewed electronic medical records of 318 patients aged 65 years or older admitted to the hospitalist-operated medical unit through the emergency department of Seoul National University Hospital. The analyzed clinical outcomes were the length of hospital stay, in-hospital mortality, unplanned intensive care unit admission, and unexpected readmission within 30 days.
resultsThe clinical outcomes did not differ between patients who took five or more drugs and those who did not. Patients with an ACB score of 3 or higher had a higher in-hospital mortality rate and longer hospital stay than those who did not. After adjusting for confounding factors, an ACB score of 3 or higher was an independent predictive factor for in-hospital mortality (odds ratio=3.09; 95% confidence interval, 1.18-8.06).
conclusionACB rather than the number of medications was associated with in-hospital mortality in acutely ill older patients. Further analytic and interventional studies are required to assess potentially inappropriate medication use and ACB in older inpatients.
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