ReviewAnnals of geriatric medicine and research2020
Motoric Cognitive Risk Syndrome: A Risk Factor for Cognitive Impairment and Dementia in Different Populations.
Review in Annals of geriatric medicine and research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07225400 (Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Impairment), which is not on this map. Cited by 62 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Impairment
Who cites it
62 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Risk factors associated with the Motoric Cognitive Risk syndrome: A meta-analysis of data from a cross-national study.Journal of the American Geriatrics Society · 2024Pooled it
- Motoric Cognitive Risk Syndrome and the Risk of Incident Dementia: A Systematic Review and Meta-Analysis of Cohort Studies.Gerontology · 2024Pooled it
- Mechanisms of motoric cognitive risk-Hypotheses based on a systematic review and meta-analysis of longitudinal cohort studies of older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Pooled it
- Nutrition and exercise interventions could ameliorate age-related cognitive decline: a meta-analysis of randomized controlled trials.Aging clinical and experimental research · 2021Pooled it
- Cost-effectiveness of 5-Cog paradigm for individuals with cognitive concerns in primary care.Public health · 2025Trial
- Associations between Finger-Dexterity Dual Task and Neuropsychological Tests in Middle-Aged and Older Adults.Annals of geriatric medicine and research · 2026Article
- Intrinsic capacity subtypes in healthy Chinese older adults: links to possible sarcopenia and fall risk.The journal of nutrition, health & aging · 2026Article
- A comprehensive German claims data analysis of care pathways, risk factors and comorbidities among acetylcholinesterase inhibitor initiators in Alzheimer's disease.Scientific reports · 2026Article
- Association between physical activity levels and motoric cognitive risk syndrome in Chinese older adults.BMC geriatrics · 2026Article
- Early Microstructural Changes in the Left Inferior Fronto-Occipital Fasciculus: A Key Factor in Probable Alzheimer's Disease Patients With Slow Gait Speed.Brain and behavior · 2026Article
- Article
- How physical activity influences motoric cognitive risk syndrome in older adults.BMC geriatrics · 2025Article
- From Dual Decline to Clinical Consequences: Mechanistic Pathways and Health Outcomes of Motoric Cognitive Risk Syndrome.Aging and disease · 2025Review
- Prefrontal Cortex Oxygenation During Exercise in Older Adults with Motoric Cognitive Risk Syndrome.Advanced biology · 2025Article
- Healthy Behavior for Preventing Cognitive Disability in Older Persons.International journal of environmental research and public health · 2025Review
- Subjective motoric cognitive risk syndrome: Preliminary prevalence from an online survey of a German cohort aged 50.Journal of Alzheimer's disease : JAD · 2025Article
- Mechanistic exploration of obesity-related indicators and motor cognitive risk syndrome: a mediated effect based on C-reactive protein triglyceride glucose index.Frontiers in aging neuroscience · 2025Article
- Bridging Pain and Motoric Cognitive Risk Syndrome: Mediating Effect of Handgrip Strength.Journal of pain research · 2025Article
- Combined association of gait speed and processing speed on cardiometabolic disease mortality risk in the US older adults: a prospective cohort study from NHANES.Frontiers in aging neuroscience · 2025Article
- Evaluation criteria for diagnosing motoric cognitive risk syndrome: a scoping review.Dementia & neuropsychologia · 2025Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Changes in gait, especially decreased gait velocity, may be a harbinger of cognitive decline in aging. Motoric cognitive risk syndrome (MCR), a pre-dementia syndrome combining slow gait and cognitive complaints, is a powerful clinical tool used to identify older adults at a high risk of developing dementia. The mean prevalence of MCR worldwide, including in a Korean cohort, was around 10%. The reported risk factors for incident MCR include older age, low education, cardiovascular disease, obesity, physical inactivity, and depression. In addition to dementia, MCR is also a risk factor for other age-related adverse conditions such as falls, disability, frailty, and mortality. The use of MCR has advantages over other pre-dementia syndromes in being much simpler to implement and requires fewer resources. Identification of mechanisms responsible for MCR may help in developing interventions to reduce the growing burden of dementia and disability worldwide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.