Evidence map›Paper›PMID 32743153›Full record

ArticleCell surface (Amsterdam, Netherlands)2020

Identification and validation of the mode of action of the chalcone anti-mycobacterial compounds.

B Anagani, J Singh, J P Bassin, G S Besra, C Benham, T R K Reddy, J A G Cox, M Goyal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell surface (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 13 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

B AnaganiSchool of Life and Medical Sciences, University of Hertfordshire, Hatfield, Herts AL10 9AB, UK.
J SinghSchool of Life and Medical Sciences, University of Hertfordshire, Hatfield, Herts AL10 9AB, UK.
J P BassinSchool of Life and Medical Sciences, University of Hertfordshire, Hatfield, Herts AL10 9AB, UK.
G S BesraInstitute of Microbiology and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
C BenhamSchool of Life and Medical Sciences, University of Hertfordshire, Hatfield, Herts AL10 9AB, UK.
T R K ReddyThe Medicines Research Group, School of Health, Sport and Biosciences, University of East London, London E15 4LZ, UK.
J A G CoxSchool of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
M GoyalSchool of Life and Medical Sciences, University of Hertfordshire, Hatfield, Herts AL10 9AB, UK.
University of Hertfordshire · GBAston University · GBUniversity of Birmingham · GBUniversity of East London · GB

Funding

Medical Research Council MR/R001154/1Medical Research Council MR/S000542/1
6 · The paper itself

Abstract

objectivesThe search for new TB drugs has become one of the great challenges for modern medicinal chemistry. An improvement in the outcomes of TB chemotherapy can be achieved by the development of new, shorter, cheap, safe and effective anti-TB regimens.

methodsChalcones (

resultsMAMEs and FAMEs analysis showed dose-dependent reduction of MAMEs with the overall abundance of FAMEs suggesting that compound

conclusionThe chalcone

Indexed as

ChalconesDockingInhAMICMycolic AcidsTuberculosis

Identifiers

PMID32743153
PMCPMC7388970
OpenAlexW3026094007

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.