Evidence map›Paper›PMID 32743098›Full record

ArticleHeliyon2020

Inhibition of complex I-III activity of brain mitochondria after intracerebroventricular administration of streptozotocin in rats is possibly related to loss of body weight.

Jit Poddar, Sukhpal Singh, Pardeep Kumar, Sharadendu Bali, Sumeet Gupta, Sasanka Chakrabarti

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jit PoddarDepartment of Biochemistry, Institute of Post-graduate Medical Education & Research, Kolkata, India.
Sukhpal SinghDepartment of Biochemistry, M M Institute of Medical Sciences & Research, Maharishi Markandeshwar Deemed University, Mullana, Ambala, India.
Pardeep KumarDepartment of Biochemistry, M M Institute of Medical Sciences & Research, Maharishi Markandeshwar Deemed University, Mullana, Ambala, India.
Sharadendu BaliDepartment of Surgery, M M Institute of Medical Sciences & Research, Maharishi Markandeshwar Deemed University, Mullana, Ambala, India.
Sumeet GuptaM M College of Pharmacy, Maharishi Markandeshwar Deemed University, Mullana, Ambala, India.
Sasanka ChakrabartiDepartment of Biochemistry, M M Institute of Medical Sciences & Research, Maharishi Markandeshwar Deemed University, Mullana, Ambala, India.
Maharishi Markandeshwar University, Mullana · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effects of streptozotocin (STZ) on the brain after intracerebroventricular (ICV) administration in rodents have been suggested to mimic the pathogenesis of sporadic Alzheimer's disease (AD). Oxidative damage, decreased glucose utilization, mitochondrial bioenergetic changes, neuroinflammation and behavioral impairment have been reported in rodents after ICV-STZ administration. However, the molecular mechanisms of STZ effects on brain after ICV administration remain highly controversial. In this study we re-examined several bioenergetic parameters of rat brain mitochondria on day 15 following ICV-STZ treatment. We observed only a moderate but statistically significant decrease in complex I-III activity in brain mitochondria from streptozotocin-treated rats. There were no changes in complex II-III activity or phosphorylation capacity of brain mitochondria after streptozotocin treatment. More importantly, it was observed that ICV-STZ treatment caused variable degrees of body-weight loss in rats, and complex I-III activity was decreased only in those rats showing a significant (more than 10%-35%) loss in body-weights.

Indexed as

Alzheimer's diseaseCognitive deficitMitochondriaMolecular neuroscienceNeuroscienceNeurotoxicologyOxidative damagePathophysiologyPharmacologyStreptozotocin

Identifiers

PMID32743098
PMCPMC7387826
OpenAlexW3044092854

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.