Evidence map›Paper›PMID 32743064›Full record

ArticlePolicy insights from the behavioral and brain sciences2018

The Value of Comparative Animal Research: Krogh's Principle Facilitates Scientific Discoveries.

Tyler J Stevenson, Beau A Alward, Francis J P Ebling, Russell D Fernald, Aubrey Kelly, Alexander G Ophir

Open access · greenAbstract read
In one paragraph

Article in Policy insights from the behavioral and brain sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Control of testes mass by androgen receptor paralogs in a cichlid.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2022
    Article
  8. Article
  9. Modular genetic control of social status in a cichlid fish.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  10. Genome sequencing and transcriptome analyses of the Siberian hamster hypothalamus identify mechanisms for seasonal energy balance.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Tyler J StevensonUniversity of Aberdeen, Scotland.
Beau A AlwardStanford University, CA, USA.
Francis J P EblingUniversity of Nottingham, UK.
Russell D FernaldStanford University, CA, USA.
Aubrey KellyCornell University, Ithaca, NY, USA.
Alexander G OphirCornell University, Ithaca, NY, USA.
Cornell University · USStanford University · USUniversity of Aberdeen · GBUniversity of Nottingham · GB

Funding

SOCIAL AND PHYSIOLOGICAL REGULATION OF MATURATIONR01NS034950 · NINDS · STANFORD UNIVERSITY · PI HELLER, H CRAIG · 1995 to 2017
$3.8M
SOCIAL AND PHYSIOLOGICAL REGULATIONS OF MATURATIONR37NS034950 · NINDS · STANFORD UNIVERSITY · PI FERNALD, RUSSELL DAWSON · 1999 to 2005
$1.9M
Influences of paternal and maternal care on offspring social cognitionR01HD079573 · NICHD · CORNELL UNIVERSITY · PI OPHIR, ALEXANDER G · 2015 to 2018
$1.3M
Social regulation of transcription and methylation networks in the brainR21NS093277 · NINDS · STANFORD UNIVERSITY · PI FERNALD, RUSSELL D · 2015 to 2016
$441k
Social and Physiological Regulation of MaturationR56NS034950 · NINDS · STANFORD UNIVERSITY · PI FERNALD, RUSSELL D · 2007 to 2007
$394k
Impact of early life family on behavior, nonapeptide systems, & epigenomeF32HD081959 · NICHD · CORNELL UNIVERSITY · PI KELLY, AUBREY MICHELLE · 2014 to 2017
$159k
NICHD NIH HHS F32 HD081959NICHD NIH HHS R01 HD079573NINDS NIH HHS R01 NS034950NINDS NIH HHS R21 NS093277NINDS NIH HHS R37 NS034950NINDS NIH HHS R56 NS034950
6 · The paper itself

Abstract

Biomedical research is dominated by relatively few nonhuman animals to investigate healthy and disease conditions. Research has overrelied on these models due to their well-described genomes, the capability to control specific genes, and the high rate of reproduction. However, recent advances in large-scale molecular sequencing experiments have revealed, in some cases, the limited similarities in experimental outcomes observed in common rodents (i.e., mice) compared with humans. The value of more varied comparative animal models includes examples such as long-term body weight regulation in seasonally breeding hamsters as a means to help understand the obesity epidemic, vocal learning in songbirds to illuminate language acquisition and maintenance, and reproduction in cichlid fish to discover novel genes conserved in humans. Studying brain genes in prairie voles and cichlids advanced knowledge about social behavior. Taken together, experiments on diverse animal species highlight nontraditional systems for advancing our understanding of human health and well-being.

Indexed as

animalbehaviormodelneuroendocrinologyphysiology

Identifiers

PMID32743064
PMCPMC7393589
OpenAlexW2767528599

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.