ArticleERJ open research2020
Amyloidosis of the respiratory system: 16 patients with amyloidosis initially diagnosed
Article in ERJ open research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Pulmonary Amyloidosis Diagnosed by Transbronchial Lung Biopsy: A Three-Case Series With Diverse Radiological Manifestations.Respirology case reports · 2026Article
- Case Report: When peripheral neuropathy meets hoarseness and cough: a diagnostic challenge and insights from a case of late-onset ATTRv.Frontiers in medicine · 2026Article
- A rare presentation of pulmonary transthyretin amyloidosis.Respiratory medicine case reports · 2025Article
- Respiratory amyloidosis: a case series from a Brazilian referral center.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2024Article
- A case of pulmonary transthyretin amyloidosis with concurrent mycobacterial tuberculosis infection.Respirology case reports · 2024Article
- A 74-Year-Old Woman With Dyspnea, Diffuse Bilateral Thickened Bronchovascular Bundle, Multiple Small Nodules, and a Thin-Walled Cavity.CHEST pulmonary · 2024Article
- Primary nodular chest amyloidoma: A case report and review of literature.Radiology case reports · 2022Article
- Tracheobronchial amyloidosis: A case report and review of literature.Radiology case reports · 2021Article
- Pulmonary amyloidosis complicated with pulmonary hemosiderosis, diagnosed with bronchoscopy.Respiratory medicine case reports · 2021Article
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background
methodsMedical records of 16 patients with amyloidosis of the respiratory system were retrospectively analysed. Amyloid was diagnosed by polarisation microscopy using Congo red-stained tissue specimens and classified immunohistochemically.
resultsMedian patient age was 71 years, and median follow-up period was 5 years. Immunoglobulin light-chain (AL)-λ amyloidosis was found in eight and AL-κ in five patients. Two patients harboured wild-type transthyretin and one harboured serum amyloid A-derived amyloid. Five different forms of amyloidosis of the respiratory system were observed: nodular pulmonary amyloidosis (seven patients), diffuse alveolar-septal amyloidosis (five), mediastinal lymph node amyloidosis (three), tracheobronchial amyloidosis (one), and pleural amyloidosis (one). One patient had diffuse alveolar-septal amyloidosis and mediastinal lymph node amyloidosis. Three of five patients with diffuse alveolar-septal amyloidosis were diagnosed by transbronchial lung biopsy as having concurrent diffuse alveolar haemorrhage or pneumocystis pneumonia. Two of three patients with mediastinal lymph node amyloidosis were diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration.
conclusionsNot only nodular pulmonary amyloidosis, diffuse alveolar-septal amyloidosis, and tracheobronchial amyloidosis but also mediastinal lymph node amyloidosis and pleural amyloidosis should be considered in the differential diagnosis of amyloidosis of the respiratory system. Useful diagnostic methods include transbronchial lung biopsy for diffuse alveolar-septal amyloidosis and endobronchial ultrasound-guided transbronchial needle aspiration for mediastinal lymph node amyloidosis.
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