ArticleQuantitative imaging in medicine and surgery2020
Association of adipose tissue and skeletal muscle metrics with overall survival and postoperative complications in soft tissue sarcoma patients: an opportunistic study using computed tomography.
Article in Quantitative imaging in medicine and surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The impact of sarcopenia on sarcoma patients: a systematic review and meta-analysis.La Radiologia medica · 2025Pooled it
- Adiposity and cancer survival: a systematic review and meta-analysis.Cancer causes & control : CCC · 2022Pooled it
- Effect of exercise modality and weight loss on changes in muscle and bone quality in older adults with obesity.Experimental gerontology · 2023Trial
- Review
- Automated CT-based visceral fat density predicts mortality regardless of visceral fat area.The British journal of radiology · 2026Article
- Sarcopenia as an independent prognostic marker in liposarcoma: A longitudinal analysis of body composition and survival.PloS one · 2026Article
- CT-assessed pectoralis major muscle measurements as risk factors for low neoadjuvant chemotherapy efficacy in osteosarcoma: a retrospective study.BMC medical imaging · 2025Article
- CT-based body composition analysis to study the effect of visceral obesity on postoperative complications in ovarian cancer: implications for young patients.World journal of surgical oncology · 2025Article
- Visceral obesity determined by CT as a predictor of short-term postoperative complications in patients with ovarian cancer.Archives of gynecology and obstetrics · 2024Article
- Sarcopenia is associated with worse surgical complications but not relapse-free survival and overall survival in patients with retroperitoneal liposarcoma.World journal of surgical oncology · 2022Article
- Adipose tissue radiodensity and mortality among patients with nonmetastatic breast cancer.Clinical nutrition (Edinburgh, Scotland) · 2022Article
- Soft tissue sarcoma: correlation of dynamic contrast-enhanced magnetic resonance imaging features with HIF-1α expression and patient outcomes.Quantitative imaging in medicine and surgery · 2022Article
- Quantitative estimation of muscle mass in older adults at risk of sarcopenia using ultrasound: a cross-sectional study.Quantitative imaging in medicine and surgery · 2022Article
- CT evaluation for sarcopenia involving the psoas and paravertebral muscles in patients with total hip arthroplasty.Skeletal radiology · 2022Article
- Impact of sarcopenia in advanced and metastatic soft tissue sarcoma.International journal of clinical oncology · 2021Article
- Marrow uptake on FDG PET/CT is associated with progression from smoldering to symptomatic multiple myeloma.Skeletal radiology · 2021Article
- Body composition imaging.Quantitative imaging in medicine and surgery · 2020Article
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11 authors.
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Abstract
backgroundTo determine the relationship between adipose tissue and skeletal muscle measurements on computed tomography (CT) and overall survival and major postoperative complications in patients with soft-tissue sarcoma (STS).
methodsThe retrospective study included 137 STS patients (75 men, 62 women; mean age, 53 years, SD 17.7; mean BMI, 28.5, SD 6.6) who had abdominal CT exams. On a single CT image, at the L4 pedicle level, measurements of visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and skeletal muscle area and attenuation were obtained using clinical PACS and specialized segmentation software. Clinical information was recorded, including STS characteristics (size, depth, grade, stage, and site), overall survival, and postoperative complications. The relationships between CT metrics and survival were analyzed using Cox proportional hazard models and those between CT metrics and postoperative complications using logistic regression models.
resultsThere were 33 deaths and 41 major postoperative complications. Measured on clinical PACS, the psoas area (P=0.003), psoas index (P=0.006), psoas attenuation (P=0.011), and total muscle attenuation (P=0.023) were associated with overall survival. Using specialized software, psoas attenuation was also associated with overall survival (P=0.018). Adipose tissue metrics were not associated with survival or postoperative complications.
conclusionsIn STS patients, CT-derived muscle size and attenuation are associated with overall survival. These prognostic biomarkers can be obtained using specialized segmentation software or routine clinical PACS.
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