ArticleRespirology case reports2020
Eosinophilic airway inflammation and eosinophilic chronic rhinosinusitis during nivolumab and ipilimumab.
Article in Respirology case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Prevalence and risk factors of persistent cough in patients diagnosed with renal cell carcinoma: a systematic review and meta-analysis.BMJ open · 2025Pooled it
- Deteriorating fractional exhaled nitric oxide preceding pneumonitis during immune checkpoint inhibitor therapy: a case report.Respiratory medicine case reports · 2026Article
- Pembrolizumab-Induced Chronic Rhinosinusitis in a Patient With Non-Small Cell Lung Cancer.Respirology case reports · 2025Article
- From Prognostic Marker to Therapeutic Agent: The Role of Nitric Oxide in Lung Cancer.Journal of clinical medicine · 2025Review
- Article
- Association of Sinonasal Symptoms and Disease With Immune Checkpoint Inhibitor Therapy.Laryngoscope investigative otolaryngology · 2025Article
- Immune Checkpoint Inhibitor (ICI) Induced Sinonasal Disease: Review of Literature and FDA Database.The Annals of otology, rhinology, and laryngology · 2024Review
- Nivolumab Therapy in Lung Cancer Associated with IgG4-related Disease.Internal medicine (Tokyo, Japan) · 2024Article
- Pembrolizumab-Induced Nasal Polyposis: The First Reported Case.Journal of rhinology : official journal of the Korean Rhinologic Society · 2023Article
- Immunotherapy-Induced Eosinophilic Tracheitis.Cureus · 2022Article
- Eosinophilic airway inflammation and eosinophilic chronic rhinosinusitis during nivolumab and ipilimumab.Respirology case reports · 2020Article
- Disappearance of MMR-deficient subclones after controlled IL-12 and PD-1 inhibition in a glioma patient.Neuro-oncology advancesArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune-related adverse events (irAEs) are induced by immune checkpoint inhibitors (ICIs) which are administered for many cancers. There are many irAEs such as endocrine abnormalities, interstitial lung disease, and colitis. However, irAEs associated with type 2 (T2) inflammation are less known. We herein report a 71-year-old woman who developed eosinophilic airway inflammation and eosinophilic chronic rhinosinusitis (ECRS) simultaneously during combination therapy with nivolumab and ipilimumab for renal cell carcinoma. After two cycles of therapy, she developed cough and nasal congestion with high level of fractioned exhaled nitric oxide and blood eosinophil count, and nasal polyps with eosinophil infiltration in bilateral nasal cavities. She was diagnosed with eosinophilic airway inflammation and ECRS, and treated with corticosteroid inhalation, steroid nasal spray, and nasal irrigation, resulting in symptom reduction. Although they are relatively rare irAEs of ICIs, clinicians should consider these diseases associated with T2 inflammation and treat appropriately.
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