Evidence map›Paper›PMID 32742600›Full record

ArticleIranian journal of basic medical sciences2020

Protective effect of interleukin-36 receptor antagonist on liver injury induced by concanavalin A in mice.

Xiao Peng, Xiuhe Pan, Jun Tan, Yan Li, Mingcai Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of basic medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. The Protective Role of IL-36/IL-36R Signal in Con A-Induced Acute Hepatitis.Journal of immunology (Baltimore, Md. : 1950) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xiao PengDepartment of Immunology, Medical School of Ningbo University, Ningbo 315211, China.
Xiuhe PanDepartment of Immunology, Medical School of Ningbo University, Ningbo 315211, China.
Jun TanDepartment of Hepatology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China.
Yan LiDepartment of Immunology, Medical School of Ningbo University, Ningbo 315211, China.
Mingcai LiDepartment of Immunology, Medical School of Ningbo University, Ningbo 315211, China.
Ningbo University · CNUniversity of Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesInterleukin-36 receptor antagonist (IL-36Ra) is a new member of the IL-1 family that exhibits anti-inflammatory activity in a variety of inflammatory and immune diseases. Our purpose was to determine the effect of IL-36Ra on liver injury in a mouse hepatitis model induced by concanavalin A (ConA). MATERIALS AND

methodsMice were treated with IL-36Ra DNA or pcDNA3.1 control plasmid using a hydrodynamic gene delivery approach.

resultsOur data reveal that treatment with IL-36Ra decreased liver inflammation and serum level of aminotransferases. Furthermore, IL-36Ra reduced ConA-induced pro-inflammatory cytokines (interferon-γ, tumor necrosis factor-α, and IL-17A) production when compared to control plasmid.

conclusionOur results demonstrated that IL-36Ra is a critical protector against ConA-induced liver injury.

Indexed as

Concanavalin A (ConA)Hydrodynamic-based gene – deliveryIL-36RaInflammationLiver injuryPlasmid

Identifiers

PMID32742600
PMCPMC7374990
OpenAlexW3013862870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.