ArticleExperimental and therapeutic medicine2020
Changes in the levels of IL-1β, cortisol and chromogranin A in saliva of subjects with occupational fatigue.
Article in Experimental and therapeutic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Salivary Stress Biomarkers (Chromogranin A and Secretory IgA): Associations with Anxiety and Depressive Symptoms in Healthcare Professionals.Nursing reports (Pavia, Italy) · 2025Article
- Article
- Exercise-Induced Central Fatigue: Biomarkers and Non-Medicinal Interventions.Aging and disease · 2024Review
- Fatigue in Inflammatory Joint Diseases.International journal of molecular sciences · 2023Review
- Wearable biosensors for human fatigue diagnosis: A review.Bioengineering & translational medicine · 2023Review
- Salivary cortisol, dehydroepiandrosterone, and chromogranin A levels in patients with gingivitis and periodontitis and a novel biomarker for psychological stress.Frontiers in endocrinology · 2023Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in the levels of interleukin-1β (IL-1β), cortisol and chromogranin A (CgA) in saliva of subjects with occupational fatigue were investigated. Doctors in the Emergency Department were selected as research subjects. Saliva was collected before work (after full rest) and after work (≥24 h). Electroencephalogram (EEG) was performed. Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of IL-1β, cortisol and CgA in saliva. In order to obtain permission for human specimens, the study was approved by the Ethics Committee of the Affiliated Hospital of Hebei University of Engineering and registered for clinical trials (registration no. ChiC-TR-DCD-14005746). As there were only 4 subjects in this study without fatigue waves in EEG, and the number of these subjects was not sufficient to constitute a control group, the comparison of the contents of IL-1β, cortisol and CgA of all subjects before and after working for 18 h was just a confirmation of the statistical results of 43 cases with fatigue waves in the EEG. According to the results, there was no change in the contents of IL-1β and cortisol in the saliva of subjects with occupational fatigue before and after fatigue, whereas, there was a significant change in the content of CgA before and after fatigue. However, there was no correlation between the content of CgA and fatigue. The results of the present study revealed that IL-1β, cortisol and CgA indicators are not suitable diagnostic markers for occupational fatigue.
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