Evidence map›Paper›PMID 32742244›Full record

ArticleSSRN2020

The Loss of Bcl-6 Expressing T Follicular Helper Cells and the Absence of Germinal Centers in COVID-19.

Naoki Kaneko, Hsiao-Hsuan Kuo, Julie Boucau, Jocelyn R Farmer, Hugues Allard-Chamard, Vinay S Mahajan, Alicja Piechocka-Trocha, Kristina Lefteri, Matt Osborn, Julia Bals and 41 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in SSRN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 36 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

51 authors at 5 institutions in 2 countries.

Naoki KanekoRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Hsiao-Hsuan KuoRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Julie BoucauRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Jocelyn R FarmerRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Hugues Allard-ChamardRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Vinay S MahajanRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Alicja Piechocka-TrochaRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Kristina LefteriRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Matt OsbornRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Julia BalsRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Yannic C BartschRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Nathalie BonheurRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Timothy M CaradonnaRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Josh ChevalierRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Fatema ChowdhuryRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Thomas J DiefenbachRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Kevin EinkaufRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Jon FallonRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Jared FeldmanRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Kelsey K FinnRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Pilar Garcia-BroncanoRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Ciputra Adijaya HartanaRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Blake M HauserRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Chenyang JiangRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Paulina KaplonekRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Marshall KarpellRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Eric C KoscherRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Xiaodong LianRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Hang LiuRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Jinqing LiuRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Ngoc L LyRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Ashlin R MichellRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Yelizaveta RassadkinaRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Kyra SeigerRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Libera SessaRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Sally ShinRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Nishant SinghRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Weiwei SunRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Xiaoming SunRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Hannah J TicheliRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Michael T WaringRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Alex L ZhuRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Jonathan LiDepartment of Medicine, Brigham and Women's Hospital, Boston, MA 02115.
Daniel LingwoodRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Aaron G SchmidtRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Matthias LichterfeldRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Bruce D WalkerRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Xu YuRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Robert F PaderaDepartment of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
Shiv PillaiRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
Massachusetts Consortium on Pathogen Readiness Specimen Working Group
Ragon Institute of MGH, MIT and Harvard · USBrigham and Women's Hospital · USBoston University · USHarvard University · USMassachusetts Institute of Technology · US

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
MOLECULAR BIOPHYSICS TRAINING GRANTT32GM008313 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MURTHY, VENKATESH N · 1989 to 2023
$14.6M
MOLECULAR BASIS OF VIRAL INFECTIVITYT32AI007245 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Aaron Gregory Schmidt · 1985 to 2026
$11.3M
The importance of the IgG4 glycome in IgG4-related disease(s)U19AI110495 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 2014 to 2026
$7.9M
Epitope focusing to the receptor binding motif for a universal coronavirus vaccineR01AI146779 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI SCHMIDT, AARON GREGORY · 2019 to 2023
$4.2M
Innate-like BCR activity as a template for universal vaccination against influenza virusR01AI137057 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CHACKERIAN, BRYCE C, LINGWOOD, DANIEL · 2018 to 2022
$2.6M
Defining and Exploiting a Genetic Template for an HIV VaccineDP2DA042422 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI LINGWOOD, DANIEL · 2016 to 2016
$2.6M
NIAID NIH HHS R01 AI137057NIAID NIH HHS R01 AI146779NIAID NIH HHS T32 AI007245NIAID NIH HHS U19 AI110495NIDA NIH HHS DP2 DA042422NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM008313
6 · The paper itself

Abstract

Humoral responses in COVID-19 disease are often of limited durability, as seen with other human coronavirus epidemics. To address the underlying etiology, we examined postmortem thoracic lymph nodes and spleens in acute SARS-CoV-2 infection and observed the absence of germinal centers, a striking reduction in Bcl-6+ germinal center B cells but preservation of AID+ B cells. Absence of germinal centers correlated with an early specific block in Bcl-6+TFH cell differentiation together with an increase in T-bet+TH1 cells and aberrant extra-follicular TNF-a accumulation.  Parallel peripheral blood studies revealed loss of transitional and follicular B cells in severe disease and accumulation of SARS-CoV-2-specific "disease-related" B cell populations. These data identify defective Bcl-6+TFH cell generation and dysregulated humoral immune induction early in COVID-19 disease, providing a mechanistic explanation for the limited durability of antibody responses in coronavirus infections and suggest that achieving herd immunity through natural infection may be difficult. Funding: This work was supported by NIH U19 AI110495 to SP, NIH R01 AI146779 to AGS, NIH R01AI137057 and DP2DA042422 to DL, BMH was supported by NIGMS T32 GM007753, TMC was supported by T32 AI007245. Funding for these studies from the Massachusetts Consortium of Pathogen Readiness, the Mark and Lisa Schwartz Foundation and Enid Schwartz is also acknowledged. Conflict of Interest: None. Ethical Approval: This study was performed with the approval of the Institutional Review Boards at the Massachusetts General Hospital and the Brigham and Women's Hospital.

Identifiers

PMID32742244
PMCPMC7385482
OpenAlexW3046864657

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.