Evidence map›Paper›PMID 32742242›Full record

ArticleSSRN2020

Single-Cell Transcriptomic Analysis of SARS-CoV-2 Reactive CD4

Benjamin J Meckiff, Ciro Ramírez-Suástegui, Vicente Fajardo, Serena J Chee, Anthony Kusnadi, Hayley Simon, Alba Grifoni, Emanuela Pelosi, Daniela Weiskopf, Alessandro Sette and 4 more

Open access · greenAbstract readPreprint
In one paragraph

Article in SSRN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 49 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Benjamin J MeckiffLa Jolla Institute for Immunology, La Jolla, CA, USA.
Ciro Ramírez-SuásteguiLa Jolla Institute for Immunology, La Jolla, CA, USA.
Vicente FajardoLa Jolla Institute for Immunology, La Jolla, CA, USA.
Serena J CheeFaculty of Medicine, University of Southampton, Southampton, UK.
Anthony KusnadiLa Jolla Institute for Immunology, La Jolla, CA, USA.
Hayley SimonLa Jolla Institute for Immunology, La Jolla, CA, USA.
Alba GrifoniLa Jolla Institute for Immunology, La Jolla, CA, USA.
Emanuela PelosiSouthampton Specialist Virology Center, University Hospitals NHS Foundation Trust, Southampton, UK.
Daniela WeiskopfLa Jolla Institute for Immunology, La Jolla, CA, USA.
Alessandro SetteLa Jolla Institute for Immunology, La Jolla, CA, USA.
Ferhat AyLa Jolla Institute for Immunology, La Jolla, CA, USA.
Grégory SeumoisLa Jolla Institute for Immunology, La Jolla, CA, USA.
Christian H OttensmeierLa Jolla Institute for Immunology, La Jolla, CA, USA.
Pandurangan VijayanandLa Jolla Institute for Immunology, La Jolla, CA, USA.
La Jolla Institute for Immunology · USUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of California, San Diego · USUniversity of Southampton · GB

Funding

Single-cell atlas of lung tissue-resident memory T cells reactive to upper and lower respiratory tract pathogensU19AI118626 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Alessandro Sette · 2015 to 2026
$36.7M
T follicular helper (Tfh) CD4+ T cell, germinal center, and antibody response dysfunction in human recurrent tonsillitisU19AI142742 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Shane P Crotty · 2019 to 2026
$32.8M
Epigenomics of T cells and innate immune cells in human asthmaR01HL114093 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI ARSHAD, SYED HASAN, PETERS, BJOERN · 2011 to 2020
$8.5M
Studying the function of human genetic variation in the light of 3D genome organizationR35GM128938 · NIGMS · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Ferhat Ay · 2018 to 2026
$4.6M
NovaSeq5000 High Throughput SequencerS10OD025052 · OD · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI SEUMOIS, GREGORY · 2018 to 2018
$832k
FACSAria II Cell SorterS10RR027366 · NCRR · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROFT, MICHAEL · 2011 to 2011
$514k
NCRR NIH HHS S10 RR027366NHLBI NIH HHS R01 HL114093NIAID NIH HHS U19 AI118626NIAID NIH HHS U19 AI142742NIGMS NIH HHS R35 GM128938NIH HHS S10 OD025052
6 · The paper itself

Abstract

The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-CoV-2 infection remains unknown. Here, we present large-scale single-cell transcriptomic analysis of viral antigen-reactive CD4+ T cells from 32 COVID-19 patients. In patients with severe disease compared to mild disease, we found increased proportions of cytotoxic follicular helper (T

Identifiers

PMID32742242
PMCPMC7385998
OpenAlexW3046475496

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.