ArticleExperimental animals2021
Low maternal licking/grooming stimulation increases pain sensitivity in male mouse offspring.
Article in Experimental animals, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Hypothalamic c-Fos expression changes during late chicken embryonic development and increases following experimental stimulation.Scientific reports · 2026Article
- Developmental Scarcity Induces Sex Differences in Social Recognition and CA2 Perineuronal Nets.eNeuro · 2026Article
- Developmental scarcity induces sex differences in social recognition and CA2 perineuronal nets.bioRxiv : the preprint server for biology · 2026Article
- Placenta-derived SOD3 deletion impairs maternal behavior via alterations in FGF/FGFR-prolactin signaling axis.Cell reports · 2024Article
- Nurture outpaces nature: fostering with an attentive mother alters social dominance in a mouse model of stress sensitivity.Molecular psychiatry · 2023Article
- Histochemical analysis of the biphasic properties of formalin pain-induced behavior.Biochemistry and biophysics reports · 2023Article
- Intergenerational transmission of maternal behavioral traits in mice: involvement of the gut microbiota.Frontiers in neuroscience · 2023Article
- Delayed Formation of Neonatal Reflexes and of Locomotor Skills Is Associated with Poor Maternal Behavior in OXYS Rats Prone to Alzheimer's Disease-like Pathology.Biomedicines · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deprivation of maternal care has been associated with higher pain sensitivity in offspring. In the present study, we hypothesized that the maternal licking/grooming behavior was an important factor for the development of the pain regulatory system. To test this hypothesis, we used male F2 offspring of early-weaned (EW) F1 mother mice that exhibit lower frequency of licking/grooming behavior. The formalin test revealed that F2 offspring of EW F1 dams showed significantly higher pain behavior than F2 offspring of normally-weaned (NW) F1 dams. We found that the mRNA levels of transient receptor potential vanilloid 1 (TRPV1), a nociceptor, were higher in the lumbosacral dorsal root ganglion (DRG) of F2 offspring of EW F1 dams than those of F2 offspring of NW F1 dams, suggesting that the higher pain sensitivity may be attributed to low licking/grooming, which may result in developmental changes in nociceptive neurons. In the DRG, mRNA levels of Mas-related G-protein coupled receptor B4 (MrgprB4), a marker of sensory neurons that detect gentle stroking, was also up-regulated in the F2 offspring of EW F1 dams. Considering that gentle touch alleviates pain, Mrgprb4 up-regulation may reflect a compensatory change. The present findings indicate important implications of maternal licking/grooming behavior in the development of the pain regulatory system.
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