ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2020
Individual Variation of Human Cortical Structure Is Established in the First Year of Life.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Lifespan trajectories of the brain's functional complexity characterized by multiscale sample entropy.NeuroImage · 2026Article
- From heterogeneity to translation: data‑driven subtyping of autism in a multilevel framework.Translational psychiatry · 2026Review
- Human cortical organoids recapitulate inter-individual variability in infant brain-growth trajectories.Cell stem cell · 2026Article
- Neonatal striatal volume is associated with infant anhedonia.Journal of affective disorders · 2026Article
- The promise of infant MRI in psychiatry: toward a framework for neural network measures in early emotional and behavioral risk identification and new intervention targets.Molecular psychiatry · 2026Review
- Early cell cycle genes in cortical organoid progenitors predict interindividual variability in infant brain growth trajectories.bioRxiv : the preprint server for biology · 2025Article
- Structural connectome gradients and their relationship to IQ in childhood.Frontiers in human neuroscience · 2025Article
- Genetic and brain similarity independently predict childhood anthropometrics and neighborhood socioeconomic conditions.Developmental cognitive neuroscience · 2024Article
- Sleep-dependent memory consolidation in young and aged brains.Aging brain · 2024Article
- Article
- Longitudinal and prospective assessment of prenatal maternal sleep quality and associations with newborn hippocampal and amygdala volume.Developmental cognitive neuroscience · 2022Article
- Maternal adverse childhood experiences and infant subcortical brain volume.Neurobiology of stress · 2022Article
- Maternal Childhood Maltreatment Is Associated With Lower Infant Gray Matter Volume and Amygdala Volume During the First Two Years of Life.Biological psychiatry global open science · 2022Article
- Prenatal and early-life environmental factors, family demographics and cortical brain anatomy in 5-year-olds: an MRI study from FinnBrain Birth Cohort.Brain imaging and behavior · 2022Article
- Age-related changes in diffuse optical tomography sensitivity profiles from childhood to adulthood.Journal of biomedical optics · 2022Article
- Audiovisual spatial recalibration but not integration is shaped by early sensory experience.iScience · 2022Article
- Brain charts for the human lifespan.Nature · 2022Article
- Genetic Influences on Longitudinal Trajectories of Cortical Thickness and Surface Area during the First 2 Years of Life.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Neurodevelopment of the association cortices: Patterns, mechanisms, and implications for psychopathology.Neuron · 2021Review
- Structural development of cortical lobes during the first 6 months of life in infant macaques.Developmental cognitive neuroscience · 2021Article
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Abstract
backgroundIndividual differences in cortical gray matter (GM) structure are associated with cognitive function and psychiatric disorders with developmental origins. Identifying when individual differences in cortical structure are established in childhood is critical for understanding the timing of abnormal cortical development associated with neuropsychiatric disorders.
methodsWe studied the development of cortical GM and white matter volume, cortical thickness, and surface area using structural magnetic resonance imaging in two unique cohorts of singleton (121 male and 131 female) and twin (99 male and 83 female) children imaged longitudinally from birth to 6 years.
resultsCortical GM volume increases rapidly in the first year of life, with more gradual growth thereafter. Between ages 1 and 6 years, total surface area expands 29%, while average cortical thickness decreases about 3.5%. In both cohorts, a large portion of individual variation in cortical GM volume (81%-87%) and total surface area (73%-83%) at age 6 years is present by age 1 year. Regional heterogeneity of cortical thickness observed at age 6 is largely in place at age 1.
conclusionsThese findings indicate that individual differences in cortical GM structure are largely established by the end of the first year of life, following a period of rapid postnatal GM growth. This suggests that alterations in GM structure associated with psychiatric disorders with developmental origins may largely arise in the first year of life and that interventions to normalize or mitigate abnormal GM development may need to be targeted to very early childhood.
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