ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2020
Refining the Empirical Constraints on Computational Models of Spatial Working Memory in Schizophrenia.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Convergent multidimensional neural phenotypes in human patients and schizophrenia-relevant mouse models identify reduced recurrent excitation in cortical circuits.medRxiv : the preprint server for health sciences · 2026Article
- A confirmatory factor analysis of hyperfocusing and inhibitory control as separable cognitive domains in schizophrenia.Journal of psychopathology and clinical science · 2026Article
- Prior Trial Effects on Working Memory in Schizophrenia, Bipolar Disorder, and Healthy Control Individuals.JAMA psychiatry · 2026Article
- A Framework for Advancing Mechanistic Neurobehavioral Biomarkers in Psychiatry.Biological psychiatry · 2026Review
- Opposite-Direction Spatial Working Memory Biases in People With Schizophrenia and Healthy Control Participants.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Dysfunctional Alpha Modulation as a Mechanism of Working Memory Impairment in Serious Mental Illness.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Qualitatively Different Delay-Dependent Working Memory Distortions in People With Schizophrenia and Healthy Control Participants.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Spatial and non-spatial feature binding impairments in visual working memory in schizophrenia.Schizophrenia research. Cognition · 2023Article
- Qualitatively different delay-dependent working memory distortions in people with schizophrenia and healthy control subjects.bioRxiv : the preprint server for biology · 2023Article
- Sex Differences in Cognition in Schizophrenia: What We Know and What We Do Not Know.Current topics in behavioral neurosciences · 2023Article
- Increased repulsion of working memory representations in schizophrenia.Journal of abnormal psychology · 2020Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundImpairments in spatial working memory (sWM) have been well documented in schizophrenia. Here we provide a comprehensive test of a microcircuit model of WM performance in schizophrenia that predicts enhanced effects of increasing delay duration and distractors based on a hypothesized imbalance of excitatory and inhibitory processes.
methodsModel predictions were tested in 41 people with schizophrenia (PSZ) and 32 healthy control subjects (HCS) performing an sWM task. In one condition, a single target location was followed by delays of 0, 2, 4, or 8 seconds. In a second condition, distractors were presented during the 4-second delay interval at 20°, 30°, 40°, 50°, or 90° from the original target location.
resultsPSZ showed less precise sWM representations than HCS, and the rate of memory drift over time was greater in PSZ than in HCS. Relative to HCS, the spatial recall responses of PSZ were more repelled by distractors presented close to the target location and more attracted by distractors presented far from the target location. The degree of attraction to distant distractors was correlated with the rate of memory drift in the absence of distractors.
conclusionsConsistent with the microcircuit model, PSZ exhibited both a greater rate of drift and greater attraction to distant distractors relative to HCS. These two effects were correlated, consistent with the proposal that they arise from a single underlying mechanism. However, the repulsion effects produced by nearby distractors were not predicted by the model and thus require an updated modeling framework.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.