Evidence map›Paper›PMID 32741603›Full record

ArticleAnnals of epidemiology2020

Association of uterine fibroids with birthweight and gestational age.

Sifang Kathy Zhao, Pingsheng Wu, Sarah H Jones, Eric S Torstenson, Katherine E Hartmann, Digna R Velez Edwards

Open access · greenAbstract read
In one paragraph

Article in Annals of epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sifang Kathy ZhaoVanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN.
Pingsheng WuDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Sarah H JonesVanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN.
Eric S TorstensonVanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN.
Katherine E HartmannVanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN; Division of Quantitative Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN.
Digna R Velez EdwardsVanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN; Division of Quantitative Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN. Electronic address: digna.r.velez.edwards@vumc.org.
Vanderbilt University Medical Center · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Consequences and Course of Uterine Fibroids in PregnancyR01HD043883 · NICHD · VANDERBILT UNIVERSITY · PI HARTMANN, KATHERINE E · 2004 to 2008
$3.1M
Non-steroidal anti-inflammatory use and miscarriageR01HD049675 · NICHD · VANDERBILT UNIVERSITY · PI HARTMANN, KATHERINE E · 2006 to 2010
$2.6M
NCATS NIH HHS UL1 TR000445NICHD NIH HHS R01 HD043883NICHD NIH HHS R01 HD049675
6 · The paper itself

Abstract

purposeTo determine if fibroids or their characteristics are associated with birthweight and/or gestational age, and to assess the impact of race or ethnicity.

methodsRight from the Start (2000-2012) is a prospective cohort that enrolled women from the southern US in early pregnancy. Transvaginal ultrasounds were used to measure fibroid characteristics and confirm gestational age. Date of birth and birthweight were obtained from vital or medical records. We assessed whether fibroid presence, number, type, and volume were associated with birthweight and/or gestational age using multivariate analysis of covariance, accounting for a priori confounders.

resultsAmong 3926 women, 416 had one or more fibroids. Mean infant birthweight and gestational age were similar among women with and without fibroids. When adjusting for race or ethnicity, all associations were attenuated. Overall, women with and without fibroids had infants of similar birthweight (-20 grams, 95% confidence interval [CI] -77, 36) and gestational age (0.4 days, 95% CI -0.9, 1.8). Women with three or more fibroids were more likely to have lighter infants (-201 grams, 95% CI -345, -58).

conclusionsRace or ethnicity substantially confounds the associations. The clinical belief that uterine fibroids impair fetal growth is supported only by a significant decrease in birthweight for women with multiple fibroids.

Indexed as

Birth WeightGestational AgeAdultCohort StudiesFemaleFetal DevelopmentHumansLeiomyomaPregnancyProspective StudiesUltrasonographyUterine NeoplasmsBirthweightConfounding factorsGestational ageLeiomyomaPregnancyProspective studies

Identifiers

PMID32741603
PMCPMC8009686
OpenAlexW3038979634

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.