Observational studyArthritis care & research2021
Relationship Between Magnetic Resonance Imaging Features and Knee Pain Over Six Years in Knees Without Radiographic Osteoarthritis at Baseline.
Observational study in Arthritis care & research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Beyond the algorithms: Challenges in predicting knee osteoarthritis pain from a machine learning point of view.Osteoarthritis imaging · 2026Article
- Bidirectional longitudinal relationships between MRI-detected structural changes and contralateral knee pain in knee osteoarthritis: Data from the Osteoarthritis Initiative.Osteoarthritis and cartilage open · 2026Article
- Associations of clinical measures and structural knee magnetic resonance imaging findings with knee symptoms in a birth cohort of 33-year-old adults.Osteoarthritis and cartilage open · 2026Article
- Optimizing Osteoarthritis Management - Therapeutic Efficacy and Evaluation of Intra-Articular Triamcinolone Acetonide Injection.Journal of pain research · 2026Review
- Comparative evaluation of weight-bearing cone beam CT arthrography and supine 3T MRI in knee osteoarthritis.Osteoarthritis imaging · 2025Article
- Association between constant and intermittent knee pain and T2 values and cartilage thickness: data from the osteoarthritis initiative.Arthritis research & therapy · 2025Article
- MRI-based patient-specific nomogram for diagnostic risk stratification of patients with early knee OA.Rheumatology (Oxford, England) · 2025Article
- Imaging-based measures of synovitis in knee osteoarthritis: A scoping review and narrative synthesis.Osteoarthritis and cartilage open · 2025Review
- Associations of Longitudinal Multiparametric MRI Findings and Clinical Outcomes in Intra-Articular Injections for Knee Osteoarthritis.Diagnostics (Basel, Switzerland) · 2024Article
- Researchers in rheumatology should avoid categorization of continuous predictor variables.BMC medical research methodology · 2023Article
- Subchondral Bone Cyst Development in Osteoarthritis: From Pathophysiology to Bone Microarchitecture Changes and Clinical Implementations.Journal of clinical medicine · 2023Review
- Osteophytes mediate the associations between cartilage morphology and changes in knee symptoms in patients with knee osteoarthritis.Arthritis research & therapy · 2022Article
- Clinical significance and management of meniscal extrusion in different knee pathologies: a comprehensive review of the literature and treatment algorithm.Knee surgery & related research · 2022Review
- Mapping knowledge structure and research trends of knee osteoarthritis with meniscus in two decades: A bibliometric analysis.Frontiers in surgery · 2022Article
- Possible role of MRI-detected osteophytes as a predictive biomarker for development of osteoarthritis of the knee: A study using data from the Osteoarthritis Initiative.Osteoarthritis and cartilage open · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
Abstract
objectiveTo explore whether magnetic resonance imaging (MRI) features suggestive of knee osteoarthritis (OA) are associated with presence of knee pain in possible early-stage OA development.
methodsWe included 294 participants from the Osteoarthritis Initiative (mean ± SD age 50 ± 3 years; 50% women) with baseline Kellgren/Lawrence grade of 0 in both knees, all of whom had received knee MRIs at 4 different time points over 6 years (baseline, 24, 48, and 72 months). Using a linear mixed model (knees matched within individuals), we studied whether MRI features (meniscal body extrusion [in mm], cartilage area loss [score 0-39], cartilage full thickness loss [range 0-16], osteophytes [range 0-29], meniscal integrity [range 0-10], bone marrow lesions [BMLs] including bone marrow cysts [range 0-20], Hoffa- or effusion-synovitis [absent/present], and popliteal cysts [absent/present]) were associated with knee-specific pain as reported on the Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire using a 0-100 scale (worst to best).
resultsThe differences in KOOS knee pain score for a knee with a 1 unit higher score on MRI were the following: meniscal extrusion -1.52 (95% confidence interval [95% CI] -2.35, -0.69); cartilage area loss -0.23 (95% CI -0.48, 0.02); cartilage full thickness loss -1.04 (95% CI -1.58, -0.50); osteophytes -0.32 (95% CI -0.61, -0.03); meniscal integrity -0.28 (95% CI -0.58, 0.02); BMLs including potential cysts -0.19 (95% CI -0.55, 0.16); synovitis 0.23 (95% CI -1.14, 1.60); and popliteal cysts 0.86 (95% CI -0.56, 2.29).
conclusionMeniscal extrusion, full thickness cartilage loss, and osteophytes are associated with having more knee pain. Although these features may be relevant targets for future trials, the clinical relevance of our findings is unclear because no feature was associated with a clinically important difference in knee pain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.