ArticleEuropean journal of neurology2020
Stressful life events are associated with the risk of multiple sclerosis.
Article in European journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Self-mastery buffers associations between stressful life events and mental quality of life and fatigue in people living with multiple sclerosis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Preventive strategies in neuroimmunology.Neurological research and practice · 2026Review
- Sympathetic innervation of human cervical lymph nodes: A potential neuroimmunomodulatory target for the treatment of T-cell-driven autoimmune diseases like MS?Journal of anatomy · 2026Article
- Depression, trauma, stressful life events and childhood infections in patients with multiple sclerosis in the Polish population - a case-control study.Postepy psychiatrii neurologii · 2026Article
- Investigating molecular background of multiple sclerosis through multi-omics: linking via psychoneuroimmunology.Acta neurologica Belgica · 2025Article
- High odds of multiple sclerosis following major life stressors: Evidence from a population-based case-control study in Northern Iran.Current journal of neurology · 2025Article
- The Polygenic Nature of Multiple Sclerosis: Genetic Variants, Immunological Modulation, and Environmental Connections.Endocrine, metabolic & immune disorders drug targets · 2025Review
- Psycho-Neuroendocrinology in the Rehabilitation Field: Focus on the Complex Interplay between Stress and Pain.Medicina (Kaunas, Lithuania) · 2024Review
- Adverse Childhood Experiences and the Risk of Multiple Sclerosis Development: A Review of Potential Mechanisms.International journal of molecular sciences · 2024Review
- Impact of the first Gulf war on multiple sclerosis risk in Kuwait: a quasi-experimental study.BMC neurology · 2023Article
- Article
- Abuse and revictimization in adulthood in multiple sclerosis: a cross-sectional study during pregnancy.Journal of neurology · 2022Article
- Association of adverse childhood experiences with the development of multiple sclerosis.Journal of neurology, neurosurgery, and psychiatry · 2022Article
- Genetic, Environmental and Lifestyle Determinants of Accelerated Telomere Attrition as Contributors to Risk and Severity of Multiple Sclerosis.Biomolecules · 2021Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeUnexpected stressful life events may alter immune function and affect susceptibility to autoimmune diseases including multiple sclerosis (MS). Current results from epidemiological investigations examining the role of stress in MS remain inconsistent. The aim was to conduct the hitherto largest population-based case-control study on this topic.
methodsExtensive questionnaire information collected on lifestyle environmental factors available for 2930 incident MS cases and 6170 controls were used to assess the association of 10 major life events that had occurred before disease onset with the risk of MS by unconditional logistic regressions, adjusting for potential confounders. Stratified analyses were also performed by sex and time.
resultsCompelling evidence was found for a link between major life events and risk of MS - most events significantly increased disease risk by 17%-30%. It was further observed that women were affected to a greater extent than men under certain stressful scenarios, and that most events that happened recently (≤5 years prior to MS onset) had significant effects on MS, indicating a critical window in disease development.
conclusionStressful life events may have an adverse effect on the risk of MS. Research into the mechanisms of this observation may give important clues to triggering pathogenetic events in MS.
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