ArticlePlant molecular biology2020
Plant-specific Dof transcription factors VASCULAR-RELATED DOF1 and VASCULAR-RELATED DOF2 regulate vascular cell differentiation and lignin biosynthesis in Arabidopsis.
Article in Plant molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 33 citations in OpenAlex.
- Mechanism and Application of Developmental Factors in Plant Genetic Transformation.International journal of molecular sciences · 2025Review
- A single-cell rice atlas integrates multi-species data to reveal cis-regulatory evolution.Nature plants · 2025Article
- Ectopic expression of wax ester synthase under a wood-specific promoter enhances cell wall production and wood hydrophobicity.Biotechnology for biofuels and bioproducts · 2025Article
- A helping hand: XND1-DOF4.6 interaction modulates Arabidopsis drought tolerance.The Plant cell · 2025Article
- A DOF transcription factor GLW9/OsDOF25 regulates grain shape and tiller angle in rice.Plant biotechnology journal · 2025Article
- Identification of theBiology · 2025Article
- The transcription factors DOF4.6 and XND1 jointly regulate root hydraulics and drought responses in Arabidopsis.The Plant cell · 2025Article
- Genome-Wide Identification and Functional Characterization of the Dof Family inInternational journal of molecular sciences · 2025Article
- Genome-Wide Identification of GmPIF Family and Regulatory Pathway Analysis of GmPIF3g in Different Temperature Environments.International journal of molecular sciences · 2025Article
- The genetics of fruit skin separation in date palm.BMC plant biology · 2024Article
- Expression of laccase and ascorbate oxidase affects lignin composition in Arabidopsis thaliana stems.Journal of plant research · 2024Article
- DOF gene family expansion and diversification.Genetics and molecular biology · 2024Article
- Integrating ATAC-seq and RNA-seq to identify differentially expressed genes with chromatin-accessible changes during photosynthetic establishment in Populus leaves.Plant molecular biology · 2023Article
- A Common Molecular Signature Indicates the Pre-Meristematic State of Plant Calli.International journal of molecular sciences · 2023Review
- A redundant transcription factor network steers spatiotemporal Arabidopsis triterpene synthesis.Nature plants · 2023Article
- DOF transcription factors: Specific regulators of plant biological processes.Frontiers in plant science · 2023Review
- Promoter and domain structures regulate FLA12 function during Arabidopsis secondary wall development.Frontiers in plant science · 2023Article
- Identification and characterization ofFrontiers in plant science · 2023Article
- Genome-wide survey and expression analysis of Dof transcription factor family in sweetpotato shed light on their promising functions in stress tolerance.Frontiers in plant science · 2023Article
- Transcription Factor DOF4.1 Regulates Seed Longevity in ArabidopsisFrontiers in plant science · 2022Article
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7 authors at 3 institutions in 1 country.
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Abstract
key messagePlant-specific Dof transcription factors VDOF1 and VDOF2 are novel regulators of vascular cell differentiation through the course of a lifetime in Arabidopsis, with shifting their transcriptional target genes. Vascular system is one of critical tissues for vascular plants to transport low-molecular compounds, such as water, minerals, and the photosynthetic product, sucrose. Here, we report the involvement of two Dof transcription factors, named VASCULAR-RELATED DOF1 (VDOF1)/VDOF4.6 and VDOF2/VDOF1.8, in vascular cell differentiation and lignin biosynthesis in Arabidopsis. VDOF genes were expressed in vascular tissues, but the detailed expression sites were partly different between VDOF1 and VDOF2. Vein patterning and lignin analysis of VDOF overexpressors and double mutant vdof1 vdof2 suggested that VDOF1 and VDOF2 would function as negative regulators of vein formation in seedlings, and lignin deposition in inflorescence stems. Interestingly, effects of VDOF overexpression in lignin deposition were different by developmental stages of inflorescence stems, and total lignin contents were increased and decreased in VDOF1 and VDOF2 overexpressors, respectively. RNA-seq analysis of inducible VDOF overexpressors demonstrated that the genes for cell wall biosynthesis, including lignin biosynthetic genes, and the transcription factor genes related to stress response and brassinosteroid signaling were commonly affected by VDOF1 and VDOF2 overexpression. Taken together, we concluded that VDOF1 and VDOF2 are novel regulators of vascular cell differentiation through the course of a lifetime, with shifting their transcriptional target genes: in seedlings, the VDOF genes negatively regulate vein formation, while at reproductive stages, the VDOF proteins target lignin biosynthesis.
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