Evidence map›Paper›PMID 32740814›Full record

ArticleEuropean radiology2021

Plaque characteristics of middle cerebral artery assessed using strategically acquired gradient echo (STAGE) and vessel wall MR contribute to misery downstream perfusion in patients with intracranial atherosclerosis.

Tong Zhang, Ruowei Tang, Song Liu, Chao Chai, Yongsheng Chen, E Mark Haacke, Shuang Xia

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Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
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6citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The incomplete circle of Willis is associated with vulnerable intracranial plaque features and acute ischemic stroke.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Article
  5. Article
  6. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tong ZhangRadiology Department, First Central Clinical College, Tianjin Medical University, Tianjin, China.
Ruowei TangRadiology Department, First Central Clinical College, Tianjin Medical University, Tianjin, China.
Song LiuRadiology Department, First Central Clinical College, Tianjin Medical University, Tianjin, China.
Chao ChaiRadiology Department, First Central Clinical College, Tianjin Medical University, Tianjin, China.
Yongsheng ChenThe MRI Institute for Biomedical Research, Detroit, MI, USA.
E Mark HaackeThe MRI Institute for Biomedical Research, Detroit, MI, USA.
Shuang XiaRadiology Department, Tianjin First Central Hospital, Number 24 of Fukang Road, Nankai District, Tianjin, China. xiashuang77@163.com.ORCID http://orcid.org/0000-0003-1626-6383

Funding

National Natural Science Foundation of China 81871342National Natural Science Foundation of China 81901728
6 · The paper itself

Abstract

objectivesTo assess plaque vulnerability of the middle cerebral artery (MCA) using strategically acquired gradient echo (STAGE) versus high-resolution vessel wall MRI (hr-vwMRI), and explore the relationship between plaque characteristics and misery downstream perfusion.

methodsNinety-one patients with single MCA atherosclerotic plaques underwent STAGE and hr-vwMRI were categorized into a group with misery perfusion and a group without based on the Alberta Stroke Program Early CT score (MTT-ASPECTS) with a threshold of 6. Plaque characteristics including inner lumen area (IWA), susceptibility, presence of hyperintensity within plaque (HIP), surface irregularity, stenosis degree, remodeling index, lipid ratio, and enhancement grade were compared between the two groups. The vulnerability of each plaque was retrospectively assessed on both STAGE and hr-vwMRI according to the combination of plaque features. Logistic regression analysis and ROC curve were performed to evaluate the effect of plaque characteristics on the presence of misery perfusion.

resultsTaking hr-vwMRI as the reference, STAGE showed good efficiency in detecting vulnerable plaques. Patients with misery perfusion had less IWA, higher stenosis degree, more irregular surface and HIP, higher enhancement grade, and susceptibility (p < 0.01 for all). Higher susceptibility and stenosis degree were independent predictors for the occurrence of misery perfusion (p = 0.025, p = 0.048). The AUC was 0.900 for the combination of the two variables.

conclusionSTAGE shows good efficiency to assess MCA plaque vulnerability versus hr-vwMRI. Plaque susceptibility evaluated using STAGE provides incremental value to predict misery perfusion combined with hr-vwMRI plaque features. KEY POINTS: • STAGE has good efficiency in evaluating MCA plaque vulnerability versus hr-vwMRI. • Higher plaque susceptibility assessed using STAGE and higher grade luminal stenosis based on hr-vwMRI attribute to misery downstream perfusion. • STAGE provides incremental value on the understanding of plaque vulnerability in addition to conventional hr-vwMRI.

Indexed as

Intracranial ArteriosclerosisPlaque, AtheroscleroticAlbertaHumansMagnetic Resonance AngiographyMagnetic Resonance ImagingMiddle Cerebral ArteryPerfusionRetrospective StudiesAtherosclerotic plaquesBrain mappingMiddle cerebral arteryPerfusion

Identifiers

PMID32740814

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.