Evidence map›Paper›PMID 32740802›Full record

ArticleMycotoxin research2020

Interactions of zearalanone, α-zearalanol, β-zearalanol, zearalenone-14-sulfate, and zearalenone-14-glucoside with serum albumin.

Zelma Faisal, Virág Vörös, Eszter Fliszár-Nyúl, Beáta Lemli, Sándor Kunsági-Máté, Miklós Poór

Open access · hybridAbstract read
In one paragraph

Article in Mycotoxin research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zelma FaisalDepartment of Pharmacology, Faculty of Pharmacy, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.
Virág VörösDepartment of Pharmacology, Faculty of Pharmacy, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.
Eszter Fliszár-NyúlDepartment of Pharmacology, Faculty of Pharmacy, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary.
Beáta LemliJános Szentágothai Research Centre, Ifjúság útja 20, Pécs, H-7624, Hungary.
Sándor Kunsági-MátéJános Szentágothai Research Centre, Ifjúság útja 20, Pécs, H-7624, Hungary.
Miklós PoórDepartment of Pharmacology, Faculty of Pharmacy, University of Pécs, Szigeti út 12, Pécs, H-7624, Hungary. poor.miklos@pte.hu.
Szent János Kórház · HUUniversity of Pecs · HU

Funding

Gazdaságfejlesztési és Innovációs Operatív Program GINOP-2.3.2-15-2016-00049Nemzeti Kutatási Fejlesztési és Innovációs Hivatal FK125166
6 · The paper itself

Abstract

The xenoestrogenic mycotoxin zearalenone is a Fusarium-derived food and feed contaminant. In mammals, the reduced (e.g., zearalanone, α-zearalanol, and β-zearalanol) and conjugated (e.g., zearalenone-14-sulfate) metabolites of zearalenone are formed. Furthermore, filamentous fungi and plants are also able to convert zearalenone to conjugated derivatives, including zearalenone-14-sulfate and zearalenone-14-glucoside, respectively. Serum albumin is the dominant plasma protein in the circulation; it interacts with certain mycotoxins, affecting their toxicokinetics. In a previous investigation, we demonstrated the remarkable species differences regarding the albumin binding of zearalenone and zearalenols. In the current study, the interactions of zearalanone, α-zearalanol, β-zearalanol, zearalenone-14-sulfate, and zearalenone-14-glucoside with human, bovine, porcine, and rat serum albumins were examined, employing fluorescence spectroscopy and affinity chromatography. Zearalanone, zearalanols, and zearalenone-14-sulfate form stable complexes with albumins tested (K = 9.3 × 10

Indexed as

Animal FeedAnimalsCattleChromatography, AffinityFusariumGlucosidesHumansMycotoxinsProtein BindingRatsSerum AlbuminSpectrometry, FluorescenceSwineZearalenoneGlucosidesMycotoxinsSerum AlbuminZearalenonezearalenone-14-glucosideSerum albuminSpecies differencesZearalanolsZearalanoneZearalenone-14-glucosideZearalenone-14-sulfate

Identifiers

PMID32740802
PMCPMC7536148
OpenAlexW3046651254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.