SynthesisJournal of neurology2021
Exploring the clinical association between neurological symptoms and COVID-19 pandemic outbreak: a systematic review of current literature.
Synthesis in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Multicentre case-control study on the association between COVID-19 vaccines and neurological disorders (COVIVAX).Scientific reports · 2025Article
- A reduced proteomic signature in critically ill Covid-19 patients determined with plasma antibody micro-array and machine learning.Clinical proteomics · 2024Article
- Possible Role of Cannabis in the Management of Neuroinflammation in Patients with Post-COVID Condition.International journal of molecular sciences · 2024Review
- SARS-CoV-2's brain impact: revealing cortical and cerebellar differences via cluster analysis in COVID-19 recovered patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Sleep disorders after COVID-19 in Czech population: Post-lockdown national online survey.Sleep medicine: X · 2023Article
- Neurological symptoms and comorbidity profile of hospitalized patients with COVID-19.Arquivos de neuro-psiquiatria · 2023Article
- SARS-CoV-2 infects aniScience · 2022Article
- Cognitive deficits and memory impairments after COVID-19 (Covishield) vaccination.Brain, behavior, & immunity - health · 2022Article
- Potential neurological manifestations of COVID-19: a narrative review.Postgraduate medicine · 2022Review
- Acute and post-acute neurological manifestations of COVID-19: present findings, critical appraisal, and future directions.Journal of neurology · 2022Review
- Public awareness of the neurological manifestation of COVID-19 in Saudi Arabia.Neurosciences (Riyadh, Saudi Arabia) · 2022Article
- Article
- Anxiety, Stress and Depression in COVID-19 Survivors From an Italian Cohort of Hospitalized Patients: Results From a 1-Year Follow-Up.Frontiers in psychiatry · 2022Article
- From asymptomatic to critical illness: decoding various clinical stages of COVID-19Turkish journal of medical sciences · 2021Article
- Post COVID-19 cerebral venous sinus thrombosis; a case report.Annals of medicine and surgery (2012) · 2021Article
- Intracranial Hemorrhage in Patients with Coronavirus Disease 2019 (COVID-19): A Case Series.World neurosurgery · 2021Article
- Prevalence of Anxiety, Depression, and Stress among Teachers during the COVID-19 Pandemic: A Rapid Systematic Review with Meta-Analysis.Brain sciences · 2021Review
- COVID-19 versus SARS: A comparative review.Journal of infection and public health · 2021Review
- Use of Antioxidants for the Neuro-Therapeutic Management of COVID-19.Antioxidants (Basel, Switzerland) · 2021Review
- Cerebral venous sinus thrombosis in patients with COVID-19 infection.Interdisciplinary neurosurgery : Advanced techniques and case management · 2021Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectThe novel severe acute respiratory syndrome (SARS)-CoV-2 outbreak has been declared a pandemic in March, 2020. An increasing body of evidence suggests that patients with the coronavirus disease (COVID-19) might have a heterogeneous spectrum of neurological symptoms
methodsA systematic search of two databases was performed for studies published up to May 29th, 2020. PRISMA guidelines were followed.
resultsWe included 19 studies evaluating 12,157 patients with laboratory-confirmed COVID-19 infections. The median age of patients was 50.3 (IQR 11.9), and the rate of male patients was 50.6% (95% CI 49.2-51.6%). The most common reported comorbidities were hypertension and diabetes (31.1%, 95% CI 30-32.3% and 13.5%, 95% CI 12.3-14.8%, respectively). Headache was reported in 7.5% of patients (95% CI 6.6-8.4%), and dizziness in 6.1% (95% CI 5.1-7.1%). Hypo/anosmia, and gustatory dysfunction were reported in 46.8 and 52.3%, of patients, respectively. Symptoms related to muscular injury ranged between 15 and 30%. Three studies reported radiological confirmed acute cerebrovascular disease in 2% of patients (95% CI 1.6-2.4%).
conclusionsThese data support accumulating evidence that a significant proportion of patients with COVID-19 infection develop neurological manifestations, especially olfactory, and gustatory dysfunction. The pathophysiology of this association is under investigation and warrants additional studies, Physicians should be aware of this possible association because during the epidemic period of COVID-19, early recognition of neurologic manifestations otherwise not explained would raise the suspect of acute respiratory syndrome coronavirus 2 infection.
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