SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2021
Dietary Inflammatory Index in relation to bone mineral density, osteoporosis risk and fracture risk: a systematic review and meta-analysis.
Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Association of dietary patterns with osteoporosis risk: a meta-analysis of observational studies.Journal of orthopaedic surgery and research · 2025Pooled it
- Gut‑bone metabolites: SCFAs, polyamines and microbial metabolomics in osteoporosis risk and therapy (Review).International journal of molecular medicine · 2026Review
- Association of dietary oxidative balance score, dietary inflammatory potential and fractures among adults aged ≥ 40 years in the United States in 1999-2018.Asia Pacific journal of clinical nutrition · 2026Article
- Mechanism of EC-EXOs-Derived THBS3 Targeting CD47 to Regulate BMSCs Differentiation to Ameliorate Bone Loss.Cell proliferation · 2025Article
- Development and evaluation of a machine learning model for osteoporosis risk prediction in Korean women.BMC women's health · 2025Article
- Attributable Risk and Consequences of Bone Mineral Density Deficits in Childhood Cancer Survivors.JAMA network open · 2025Article
- Emerging Role of Enzyme-Immobilized Nanocarriers in Osteoporosis: Advances and Challenges.International journal of nanomedicine · 2025Review
- Trends and hotspots in research on osteoporosis and nutrition from 2004 to 2024: a bibliometric analysis.Journal of health, population, and nutrition · 2024Review
- Monitoring of bone matrix acidification by TRAP and ERK biomarkers in the chronic hypercholesterolemia male rats.Open veterinary journal · 2024Article
- Health Outcome Comparison Based on Dietary Inflammatory Levels among Sample of Korean Elderly.Healthcare (Basel, Switzerland) · 2024Article
- Dietary inflammatory pattern and risk of hip fracture in the Nurses' Health Study.Archives of osteoporosis · 2024Article
- Vascular endothelial cells-derived exosomes synergize with curcumin to prevent osteoporosis development.iScience · 2024Article
- Lacto-ovo-vegetarian diet is inversely associated with the osteosarcopenia in older adults.BMC geriatrics · 2024Article
- The association between dietary inflammation index and bone mineral density: results from the United States National Health and nutrition examination surveys.Renal failure · 2023Article
- Association of Alternative Dietary Patterns with Osteoporosis and Fracture Risk in Older People: A Scoping Review.Nutrients · 2023Article
- Association Between the Dietary Inflammatory Index and the Risk of Fracture in Chinese Adults: Longitudinal Study.JMIR public health and surveillance · 2023Article
- Risk factors associated with low bone mineral density in children with idiopathic scoliosis: a scoping review.BMC musculoskeletal disorders · 2023Article
- BMI, socioeconomic status, and bone mineral density in U.S. adults: Mediation analysis in the NHANES.Frontiers in nutrition · 2023Article
- Fracture Risk in Vegetarians and Vegans: the Role of Diet and Metabolic Factors.Current osteoporosis reports · 2022Review
- Dietary inflammatory index and osteoporosis: the National Health and Nutrition Examination Survey, 2017-2018.Endocrine · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Our systematic review and meta-analysis indicated that pro-inflammatory diets, as measured by higher Dietary Inflammatory Index scores, are significantly associated with lower BMD of lumbar spine and total hip as well as elevated risk of osteoporosis and fractures. These findings may contribute to the development of public health strategies.
introductionInflammatory Index (DII) is a method to assess the inflammatory potential of diets; it has been reported to be associated with several diseases. However, the relation between DII and bone health remains controversial for the inconsistent findings from previous studies. This systematic review and meta-analysis aimed to ascertain the underlying relationships between DII and bone mineral density (BMD), osteoporosis risk, and fracture risk.
methodsWe systematically searched PubMed and Web of Science for all relevant epidemiological studies published up to May 1, 2020. Fixed-effects model or random-effects model was employed to pool the study-specific effect sizes (ESs) and 95% confidence intervals (CIs).
resultsEleven studies with a total of 127,769 participants were included. We found that continuous DII was negatively associated with BMD of lumbar spine (odds ratios [OR]: 0.990; 95% CI: 0.984, 0.995) and total hip (OR: 0.995; 95% CI: 0.990, 0.999), but not femoral neck (OR: 0.998; 95% CI: 0.994, 1.002). Moreover, the highest category of DII displayed significantly associations to increased risk of osteoporosis (ES: 1.31; 95% CI: 1.16, 1.48) and fractures (ES: 1.28; 95% CI: 1.03, 1.59) compared with the lowest category of DII, respectively.
conclusionOur analysis indicated that diets with high pro-inflammatory components might increase the risk of osteoporosis and fractures and lower BMD of lumbar spine and total hip. More prospective studies involving populations of diverse ages and genders are expected to further verify the universality of the results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.