ArticleEBioMedicine2020
Dissociations in cortical thickness and surface area in non-comorbid never-treated patients with social anxiety disorder.
Article in EBioMedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Grey matter structural alterations in anxiety disorders: a voxel-based meta-analysis.Brain imaging and behavior · 2024Pooled it
- Candidate Biological Markers for Social Anxiety Disorder: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Epidemiology, genetics, neuroimaging, clinical features, and treatment between overall and performance-only social anxiety disorder: a narrative review.Dialogues in clinical neuroscience · 2026Review
- Cognitive Function Deficits Associated With Type 2 Diabetes and Retinopathy: Volumetric Brain MR Imaging Study.Brain and behavior · 2025Article
- Disrupted Cross-Scale Network Associated With Cognitive-Emotional Disorders in Sudden Sensorineural Hearing Loss.CNS neuroscience & therapeutics · 2025Article
- The Adaptive Role of Entorhinal Cortical Thickness in Post-COVID 19 Cognitive Impairment.Noro psikiyatri arsivi · 2025Article
- Abnormal large-scale brain functional network dynamics in social anxiety disorder.CNS neuroscience & therapeutics · 2024Article
- Impact of Stress on Brain Morphology: Insights into Structural Biomarkers of Stress-related Disorders.Current neuropharmacology · 2024Review
- Altered cortical thickness of the superior frontal gyrus and fusiform gyrus in individuals with subthreshold social anxiety.Scientific reports · 2023Article
- Pre-COVID brain network topology prospectively predicts social anxiety alterations during the COVID-19 pandemic.Neurobiology of stress · 2023Article
- Large-scale brain functional network abnormalities in social anxiety disorder.Psychological medicine · 2023Article
- Large-scale dysfunctional white matter and grey matter networks in patients with social anxiety disorder.iScience · 2022Article
- Evidence of genetic overlap and causal relationships between blood-based biochemical traits and human cortical anatomy.Translational psychiatry · 2022Article
- The relationship between craving and insular morphometry in regular cocaine users: Does sex matter?Addiction biology · 2022Article
- Structural and functional deficits and couplings in the cortico-striato-thalamo-cerebellar circuitry in social anxiety disorder.Translational psychiatry · 2022Article
- Emotional intelligence mediates the association between middle temporal gyrus gray matter volume and social anxiety in late adolescence.European child & adolescent psychiatry · 2021Article
- Alterations in the Occipital Cortex of Drug-Naïve Adults With Major Depressive Disorder: A Surface-Based Analysis of Surface Area and Cortical Thickness.Psychiatry investigation · 2021Article
- Intrinsic functional connectivity in families genetically enriched for social anxiety disorder - an endophenotype study.EBioMedicine · 2021Article
- Gray matter matters: The structure of the socially-anxious brain.EBioMedicine · 2020Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbnormalities of functional activation and cortical volume in brain regions involved in the neurobiology of fear and anxiety have been implicated in the pathophysiology of social anxiety disorder (SAD). However, few studies have performed separate measurements of cortical thickness (CT) and cortical surface area (CSA) which reflect different neurobiological processes. Thus, we aimed to explore the cortical morphological anomaly separately in SAD using FreeSurfer.
methodsHigh-resolution structural magnetic resonance images were obtained from 32 non-comorbid never-treated adult SAD patients and 32 demography-matched healthy controls. Cortical morphometry indices including CT and CSA were separately determined by FreeSurfer and compared between the two groups via whole-brain vertex-wise analysis, while partial correlation analysis using age and gender as covariates were conducted.
findingsThe patients with SAD showed decreased CT but increased CSA near-symmetrically in the bilateral prefrontal cortex (PFC) of the dorsolateral, dorsomedial, and ventromedial subdivisions, as well as the right lateral orbitofrontal cortex; increased CSA in the left superior temporal gyrus (STG) was also observed in SAD. The CSA in the left PFC was negatively correlated with the disease duration.
interpretationAs the balloon model hypothesis suggests that the tangentially stretched cortex may cause dissociations in cortical morphometry and affect the cortical capacity for information processing, our findings of dissociated morphological alterations in the PFC and cortical expansion in the STG may reflect the morphological alterations of the functional reorganization in those regions, and highlight the important role of those structures in the pathophysiology and neurobiology of SAD.
fundingThis study was funded by the National Natural Science Foundation of China (Grant Nos. 31700964, 31800963, 81621003, and 81820108018).
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