Evidence map›Paper›PMID 32739864›Full record

ArticleEBioMedicine2020

A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice.

Chloé Amouyal, Julien Castel, Claudiane Guay, Amélie Lacombe, Jessica Denom, Stéphanie Migrenne-Li, Christine Rouault, Florian Marquet, Eleni Georgiadou, Theodoros Stylianides and 9 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  4. Review
  5. Article
  6. Intravital imaging of islet CaNature communications · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 4 countries.

Chloé AmouyalSorbonne Université, INSERM, Nutrition and Obesities; Systemic approaches (NutriOmics), Paris, France; AP-HP, Pitié-Salpêtrière Hospital, Diabetology department, F-75013 Paris, France.
Julien CastelUniversité de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France.
Claudiane GuayDepartment of Fundamental Neurosciences, University of Lausanne, Rue du Bugnon 9, CH-1005, Lausanne, Switzerland.
Amélie LacombePreclinICAN, Institute of Cardiometabolism and Nutrition, Paris, France.
Jessica DenomUniversité de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France.
Stéphanie Migrenne-LiUniversité de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France.
Christine RouaultSorbonne Université, INSERM, Nutrition and Obesities; Systemic approaches (NutriOmics), Paris, France.
Florian MarquetSorbonne Université, INSERM, Nutrition and Obesities; Systemic approaches (NutriOmics), Paris, France.
Eleni GeorgiadouSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Theodoros StylianidesLoughborough University, Loughborough, UK.
Serge LuquetUniversité de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France.
Hervé Le StunffUniversité de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France.
Raphael ScharfmannUniversité de Paris, Cochin Institute, Inserm U1016, Paris 75014, France.
Karine ClémentSorbonne Université, INSERM, Nutrition and Obesities; Systemic approaches (NutriOmics), Paris, France; APHP, Pitié-Salpêtrière Hospital, Nutrition department, F-75013 Paris, France.
Guy A RutterSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK; Lee Kong Chian School of Medicine, Nan Yang Technological University, Singapore.
Olivier TaboureauUniversité de Paris, BFA, Team CMPLI, Inserm U1133, CNRS UMR 8251, Paris, France.
Christophe MagnanUniversité de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France.
Romano RegazziDepartment of Fundamental Neurosciences, University of Lausanne, Rue du Bugnon 9, CH-1005, Lausanne, Switzerland; Department of Biomedical Sciences, University of Lausanne, Rue du Bugnon 7, CH-1005 Lausanne, Switzerland.
Fabrizio AndreelliSorbonne Université, INSERM, Nutrition and Obesities; Systemic approaches (NutriOmics), Paris, France; AP-HP, Pitié-Salpêtrière Hospital, Diabetology department, F-75013 Paris, France. Electronic address: fabrizio.andreelli@aphp.fr.
Centre National de la Recherche Scientifique · FRImperial College London · GBInserm · FRNutrition et obésité : approches systémiques · FRUnit of Functional and Adaptive Biology · FRUniversité Paris Cité · FRUniversity of Lausanne · CHFondation pour l’innovation en Cadiométabolisme et Nutrition · FRInstitut Cochin · FRLoughborough University · GBSorbonne Université · FR

Funding

Medical Research Council MR/K001981/1Medical Research Council MR/K023667/1Medical Research Council MR/L020149/1Medical Research Council MR/L02036X/1Medical Research Council MR/M012646/1Medical Research Council MR/N020472/1Medical Research Council MR/R010676/1Medical Research Council MR/R022259/1
6 · The paper itself

Abstract

backgroundBariatric surgery is an effective treatment for type 2 diabetes. Early post-surgical enhancement of insulin secretion is key for diabetes remission. The full complement of mechanisms responsible for improved pancreatic beta cell functionality after bariatric surgery is still unclear. Our aim was to identify pathways, evident in the islet transcriptome, that characterize the adaptive response to bariatric surgery independently of body weight changes.

methodsWe performed entero-gastro-anastomosis (EGA) with pyloric ligature in leptin-deficient ob/ob mice as a surrogate of Roux-en-Y gastric bypass (RYGB) in humans. Multiple approaches such as determination of glucose tolerance, GLP-1 and insulin secretion, whole body insulin sensitivity, ex vivo glucose-stimulated insulin secretion (GSIS) and functional multicellular Ca

findingsEGA resolved diabetes, increased pancreatic insulin content and GSIS despite a persistent increase in fat mass, systemic and intra-islet inflammation, and lipotoxicity. Surgery differentially regulated 193 genes in the islet, most of which were involved in the regulation of glucose metabolism, insulin secretion, calcium signaling or beta cell viability, and these were normalized alongside changes in glucose metabolism, intracellular Ca

interpretationTaken together, our data highlight novel miRNA-gene interactions in the pancreatic islet during the resolution of diabetes after bariatric surgery that form part of a blood signature of diabetes reversal.

fundingEuropean Union's Horizon 2020 research and innovation programme via the Innovative Medicines Initiative 2 Joint Undertaking (RHAPSODY), INSERM, Société Francophone du Diabète, Institut Benjamin Delessert, Wellcome Trust Investigator Award (212625/Z/18/Z), MRC Programme grants (MR/R022259/1, MR/J0003042/1, MR/L020149/1), Diabetes UK (BDA/11/0004210, BDA/15/0005275, BDA 16/0005485) project grants, National Science Foundation (310030-188447), Fondation de l'Avenir.

Indexed as

Gene Regulatory NetworksAnimalsDiabetes Mellitus, Type 2Disease Models, AnimalGastric BypassGene Expression ProfilingGene Expression RegulationGlucagon-Like Peptide 1Glucose Tolerance TestHumansInsulinInsulin-Secreting CellsMaleMiceMice, ObeseMicroRNAsGlucagon-Like Peptide 1InsulinMicroRNAsBariatric surgeryBeta cell functionDiabetesInsulin secretionmicroRNAob/ob mouse

Identifiers

PMID32739864
PMCPMC7393530
OpenAlexW3045975028

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.