ArticleiScience2020
Dioxygen Activation by Internally Aromatic Metallacycle: Crystallographic Structure and Mechanistic Investigations.
Article in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 14 citations in OpenAlex.
- Integrating Machine Learning With Constant-Potential Simulation to Unravel Charge-Transfer Mechanisms in Electrochemical Nitrogen Fixation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- An osmium-peroxo complex for photoactive therapy of hypoxic tumors.Nature communications · 2022Article
- Recent Advances in the Reactions of Cyclic Carbynes.Molecules (Basel, Switzerland) · 2020Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mononuclear metal-peroxo species are invoked as the key intermediates in metalloenzymatic or synthetic catalysis. However, either transience or sluggishness reactivity of synthetic analogs of metal-peroxo species impedes our understanding of oxygen activation mechanism. Herein, we designed and characterized a dioxygen-derived mononuclear osmium-peroxo complex, in which the peroxo ligand is stabilized by internally aromatic metallacycle. We demonstrate that the osmium-peroxo species shows catalytic activity toward promoterless alcohol dehydrogenations. Furthermore, computational studies provide a new mechanism for the osmium-peroxo-mediated alcohol oxidation, starting with the concerted double-hydrogen transfer and followed by the generation of osmium-oxo species. Interestingly, the internally aromatic metallacycle also plays a vital role in catalysis, which mediates the hydrogen transfer from osmium center to the distal oxygen atom of Os-OOH moiety, thus facilitating the Os-OOH→Os=O conversion. We expect that these insights will advance the development of aromatic metallacycle toward aerobic oxidation catalysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.