ReviewJournal of reproductive immunology2020
What immunological and hormonal protective factors lower the risk of COVID-19 related deaths in pregnant women?
Review in Journal of reproductive immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Expression Levels of PF4, ALOX12, ITGA2B, F131A in Pregnant COVID-19 Survivors.Biochemical genetics · 2025Article
- Genital Dysbiosis and Different Systemic Immune Responses Based on the Trimester of Pregnancy in SARS-CoV-2 Infection.International journal of molecular sciences · 2024Article
- Severity of COVID-19 in Pregnant Women: A Review on the Potential Role of Regulatory T Cells.Current medicinal chemistry · 2024Review
- COVID-19 and tuberculosis co-infection in pregnancy - A case series and review.Journal of mother and child · 2022Article
- The therapeutic potential of regulatory T cells in reducing cardiovascular complications in patients with severe COVID-19.Life sciences · 2022Review
- The percentage of CD39+ monocytes is higher in pregnant COVID-19+ patients than in nonpregnant COVID-19+ patients.PloS one · 2022Article
- Pregnancy and Birth Outcomes during the Early Months of the COVID-19 Pandemic: The MOACC-19 Cohort.International journal of environmental research and public health · 2021Article
- Will prenatal exposure to SARS-CoV-2 define a birth cohort with accelerated aging in the century ahead?Journal of developmental origins of health and disease · 2021Review
- COVID-19 in Africa: an ovarian victory?Journal of ovarian research · 2021Review
- Chronic Active Hepatitis B with COVID-19 in Pregnancy: A Case Report.Journal of clinical and translational hepatology · 2021Article
- Immune Response to COVID-19 During Pregnancy.Frontiers in immunology · 2021Article
- SARS-CoV-2 Infection in Pregnant Women: Neuroimmune-Endocrine Changes at the Maternal-Fetal Interface.Neuroimmunomodulation · 2021Review
- Sex and COVID-19: A Protective Role for Reproductive Steroids.Trends in endocrinology and metabolism: TEM · 2021Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite anticipated increased risk of COVID-19 and increased expression of the SARS CoV-2 receptor (ACE2), the relatively low mortality of pregnant women with COVID-19 has been an area of wonder. The immunological changes predominantly inclining to anti-inflammatory state, which is augmented by placental hormones' immune modulating action, looks against with COVID-19 inflammatory reaction leading to cytokine storm and multiple organ failure. Unlike many other viral infections, the bilateral immune activation of COVID-19 may preferentially make pregnant women at low risk. Taking the physiological advantage of pregnant women, potential clinical trials are proposed. Quite a large number of epidemiological and obstetrics related studies have addressed the cases of women with COVID-19. However, to the best of the author's knowledge, little is done to explore the physiological internal milieu of pregnant women in relation to COVID-19. This review provides an insight into how the hormonal and immunological changes in pregnancy potentially reduce SARS-CoV-2-mediated inflammatory response.
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