ArticleThe New phytologist2021
The FUSED LEAVES1-ADHERENT1 regulatory module is required for maize cuticle development and organ separation.
Article in The New phytologist, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 35 citations in OpenAlex.
- A single-nucleus atlas of ligular region uncovers brassinosteroid-driven cell fate transitions controlling leaf angle in maize.Nature communications · 2026Article
- Transcriptional control of cuticle formation during development.Journal of experimental botany · 2026Review
- Identification of Leaf Waxy Candidate Gene and Expression Changes in Related Genes in Response to Cold Stress of Cabbage (Current issues in molecular biology · 2026Article
- Genetic interaction between GL15 and FDL1 modulates juvenile cuticle deposition and leaf permeability in maize.Journal of experimental botany · 2025Article
- Single-cell sequencing and mass spectrometry imaging reveal the multicellular compartmentalization map of plant triterpenes: A ginsenoside in Panax ginseng example.Plant biotechnology journal · 2025Article
- Single-cell transcriptomic profiling of maize cell heterogeneity and systemic immune responses against Puccinia polysora Underw.Plant biotechnology journal · 2025Article
- Transcriptional corepressors in maize maintain meristem development.Plant physiology · 2024Article
- Cuticle development and the underlying transcriptome-metabolome associations during early seedling establishment.Journal of experimental botany · 2024Article
- Integrative multi-omic analysis identifies genes associated with cuticular wax biogenesis in adult maize leaves.G3 (Bethesda, Md.) · 2024Article
- A GDSL-motif Esterase/Lipase Affects Wax and Cutin Deposition and Controls Hull-Caryopsis Attachment in Barley.Plant & cell physiology · 2024Article
- Genetic variation in ZmWAX2 confers maize resistance to Fusarium verticillioides.Plant biotechnology journal · 2023Article
- Epicuticular wax accumulation and regulation of wax pathway gene expression during bioenergy Sorghum stem development.Frontiers in plant science · 2023Article
- Roles of theFrontiers in plant science · 2023Article
- Modifying the yeast very long chain fatty acid biosynthetic machinery by the expression of plant 3-ketoacyl CoA synthase isozymes.Scientific reports · 2022Article
- Article
- Molecular Cloning and Functional Analysis ofInternational journal of molecular sciences · 2021Article
- A seed coat-specific β-ketoacyl-CoA synthase, KCS12, is critical for preserving seed physical dormancy.Plant physiology · 2021Article
- Dissecting the Roles of Cuticular Wax in Plant Resistance to Shoot Dehydration and Low-Temperature Stress inInternational journal of molecular sciences · 2021Article
- The Genetic Control of the Compound Leaf Patterning inFrontiers in plant science · 2021Review
- Drought-ResponsivePlant physiology · 2020Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All aerial epidermal cells in land plants are covered by the cuticle, an extracellular hydrophobic layer that provides protection against abiotic and biotic stresses and prevents organ fusion during development. Genetic and morphological analysis of the classic maize adherent1 (ad1) mutant was combined with genome-wide binding analysis of the maize MYB transcription factor FUSED LEAVES1 (FDL1), coupled with transcriptional profiling of fdl1 mutants. We show that AD1 encodes an epidermally-expressed 3-KETOACYL-CoA SYNTHASE (KCS) belonging to a functionally uncharacterized clade of KCS enzymes involved in cuticular wax biosynthesis. Wax analysis in ad1 mutants indicates that AD1 functions in the formation of very-long-chain wax components. We demonstrate that FDL1 directly binds to CCAACC core motifs present in AD1 regulatory regions to activate its expression. Over 2000 additional target genes of FDL1, including many involved in cuticle formation, drought response and cell wall organization, were also identified. Our results identify a regulatory module of cuticle biosynthesis in maize that is conserved across monocots and eudicots, and highlight previously undescribed factors in lipid metabolism, transport and signaling that coordinate organ development and cuticle formation.
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