Evidence map›Paper›PMID 32738777›Full record

ReviewPhysica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)2020

Machine learning in quantitative PET: A review of attenuation correction and low-count image reconstruction methods.

Tonghe Wang, Yang Lei, Yabo Fu, Walter J Curran, Tian Liu, Jonathon A Nye, Xiaofeng Yang

Abstract readReview
In one paragraph

Review in Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed.

  1. Article
  2. Article
  3. Clinical evaluation of deep learning-based CT-free PET reconstruction image: a dual-center study.European journal of nuclear medicine and molecular imaging · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Sex-Based Bias in Artificial Intelligence-Based Segmentation Models in Clinical Oncology.Clinical oncology (Royal College of Radiologists (Great Britain)) · 2025
    Review
  8. PE-CycleGAN network based CBCT-sCT generation for nasopharyngeal carsinoma adaptive radiotherapy.Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tonghe WangDepartment of Radiation Oncology, Emory University, Atlanta, GA, USA; Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Yang LeiDepartment of Radiation Oncology, Emory University, Atlanta, GA, USA.
Yabo FuDepartment of Radiation Oncology, Emory University, Atlanta, GA, USA.
Walter J CurranDepartment of Radiation Oncology, Emory University, Atlanta, GA, USA; Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Tian LiuDepartment of Radiation Oncology, Emory University, Atlanta, GA, USA; Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Jonathon A NyeDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
Xiaofeng YangDepartment of Radiation Oncology, Emory University, Atlanta, GA, USA; Winship Cancer Institute, Emory University, Atlanta, GA, USA. Electronic address: xiaofeng.yang@emory.edu.

Funding

Multiparametric MRI-guided Prostate HDR Brachytherapy with Focal Tumor BoostR01CA215718 · NCI · EMORY UNIVERSITY · PI YANG, XIAOFENG · 2018 to 2022
$1.8M
NCI NIH HHS R01 CA215718
6 · The paper itself

Abstract

The rapid expansion of machine learning is offering a new wave of opportunities for nuclear medicine. This paper reviews applications of machine learning for the study of attenuation correction (AC) and low-count image reconstruction in quantitative positron emission tomography (PET). Specifically, we present the developments of machine learning methodology, ranging from random forest and dictionary learning to the latest convolutional neural network-based architectures. For application in PET attenuation correction, two general strategies are reviewed: 1) generating synthetic CT from MR or non-AC PET for the purposes of PET AC, and 2) direct conversion from non-AC PET to AC PET. For low-count PET reconstruction, recent deep learning-based studies and the potential advantages over conventional machine learning-based methods are presented and discussed. In each application, the proposed methods, study designs and performance of published studies are listed and compared with a brief discussion. Finally, the overall contributions and remaining challenges are summarized.

Indexed as

Image Processing, Computer-AssistedMultimodal ImagingBrainMachine LearningMagnetic Resonance ImagingPositron-Emission TomographyAttenuation correctionLow-count PETMachine learningPETPositron emission tomography

Identifiers

PMID32738777
PMCPMC7484241

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.