Evidence map›Paper›PMID 32738613›Full record

ArticleiScience2020

Dysregulation of RyR Calcium Channel Causes the Onset of Mitochondrial Retrograde Signaling.

Anindya Roy Chowdhury, Satish Srinivasan, György Csordás, György Hajnóczky, Narayan G Avadhani

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Mitochondrial Metal Ion Transport in Cell Metabolism and Disease.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Anindya Roy ChowdhuryDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Satish SrinivasanDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
György CsordásMitocare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
György HajnóczkyMitocare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Narayan G AvadhaniDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: narayan@vet.upenn.edu.
University of Pennsylvania · USThomas Jefferson University · US

Funding

Role of Mitochondria-Targeted CYP2D6 in Chemical ToxicityR01GM034883 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI AVADHANI, NARAYAN G · 1985 to 2018
$6.1M
Mitochondria-SR Tethering: Its Role in Cardiac Bioenergetics and Ca2+ DynamicsR01HL122124 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI CSORDAS, GYORGY, SHEU, SHEY-SHING · 2014 to 2025
$4.0M
Role of Mitochondrial Respiratory Stress Signaling in Cancer ProgressionR01CA022762 · NCI · UNIVERSITY OF PENNSYLVANIA · PI AVADHANI, NARAYAN G · 1985 to 2013
$3.3M
MITOCHONDRIAL D-LOOP DNA MUTATIONS AND GENE EXPRESSIONR37CA022762 · NCI · UNIVERSITY OF PENNSYLVANIA · PI AVADHANI, NARAYAN G · 1994 to 2002
$299k
NCI NIH HHS R01 CA022762NCI NIH HHS R37 CA022762NIGMS NIH HHS R01 GM034883
6 · The paper itself

Abstract

This study shows that multiple modes of mitochondrial stress generated by partial mtDNA depletion or cytochrome c oxidase disruption cause ryanodine receptor channel (RyR) dysregulation, which instigates the release of Ca

Indexed as

Biological SciencesCell BiologyMolecular Biology

Identifiers

PMID32738613
PMCPMC7394923
OpenAlexW3042926336

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.