Evidence map›Paper›PMID 32738520›Full record

ReviewJournal of sport and health science2021

Roles and molecular mechanisms of physical exercise in cancer prevention and treatment.

Qiaoyun Wang, Wenli Zhou

3 registry-linked trialsOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of sport and health science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 107 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 13 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06429189 naunknown statusnot on this mapstarted 2024, after this paper: background citation

An Online Home-based Combined Exercise Intervention With Self-selected Intensity for Women With Breast Cancer: The Home-Combo Randomized Controlled Trial.

TypeinterventionalSponsorGrupo LusófonaRan2024 to 2025Enrolled98ConditionsBreast Cancer, Chemotherapy EffectArmsHome-based combined exercise program with self-selected intensity
NCT06540495 narecruitingnot on this mapstarted 2024, after this paper: background citation

Virtual Personalized Exercise Program for Subjects With Lung Cancer: a Feasibility Study

TypeinterventionalSponsorNorthwell HealthRan2024 to 2025Enrolled60ConditionsLung CancerArmsSalaso Virtual Exercise Program
NCT07453173 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Pilot, Single-Arm, Prospective Study Assessing Feasibility and Safety of a Supervised Progressive Resistance Training Program During Total NeoadjuvantTherapy (RAPIDO) Until Surgery in Locally Advanced Rectal Cancer

TypeinterventionalSponsorFundacion Arturo Lopez PerezRan2026 to 2027Enrolled15ConditionsLocally Advanced Rectal CancerArmsStrength training program
3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 13 syntheses or guidelines pooled it, 180 citations in OpenAlex.

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  14. Physical Exercise in Immunotherapy.Sports medicine - open · 2026
    Review
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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Qiaoyun WangDepartment of Oncology, Shanghai Fourth People's Hospital Affiliated of Tongji University School of Medicine, Shanghai 200081, China; Department of Oncology, The Second Affiliated Hospital of Soochow University, Soochow 215004, China.
Wenli ZhouDepartment of Medical Oncology, Changzheng Hospital, Navy Medical University, Shanghai 200070, China. Electronic address: doctorwinly@126.com.
Second Military Medical University · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exercise can enhance motivation to change lifestyle behaviors, improve aerobic fitness, improve physical function, control fatigue, and enhance quality of life. Studies have demonstrated the benefits to be gained from physical exercise, highlighting the importance of popularizing the concept of physical exercise for individuals and making professional exercise-treatment programs available to patients with cancer. However, the correlation between physical exercise and carcinogenesis is easily overlooked, and exercise interventions are not routinely provided to patients with cancer, especially those with advanced cancer. In this article, we present a literature review of the effects of exercise on cancer development and progression and give recent evidence for the type of exercise best suited for different types of cancer and in different disease stages. Moreover, the molecular mechanisms about regulating metabolism and systemic immune function in cancer are summarized and discussed. In conclusion, physical exercise should be considered as an important intervention for preventing and treating cancer and its complications.

Indexed as

Antineoplastic AgentsApoptosisCell ProliferationExerciseFatigueFemaleHumansLife StyleMaleMolecular Targeted TherapyNeoplasmsPrognosisRisk FactorsAntineoplastic AgentsCancer developmentCancer treatmentMolecular mechanismsPhysical exercise

Identifiers

PMID32738520
PMCPMC7987556
OpenAlexW3045892563

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.