ReviewNeuropharmacology2020
Nicotinic acetylcholine receptors and nicotine addiction: A brief introduction.
Review in Neuropharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 1 synthesis or guideline pooled it, 174 citations in OpenAlex.
- Efficacy of combined varenicline and nicotine replacement therapy compared with varenicline or nicotine replacement therapy alone for smoking cessation: A systematic review and meta-analysis.Addiction (Abingdon, England) · 2026Pooled it
- Nicotine use and psychoticism: A longitudinal co-twin control analysis.Journal of psychopathology and clinical science · 2026Article
- Spatially Resolved Multi-Omics Reveals Brain-Kidney Compartmentalization and Region-Specific Molecular Reprogramming After Acute Nicotine Exposure.Metabolites · 2026Article
- Effort and substance use: differentiating tobacco use through reinforcement learning of effort based decision making.Journal of computational neuroscience · 2026Article
- Nicotine-Mediated Redox and Nitrosative Stress in Cardiorenal Health.Hypertension (Dallas, Tex. : 1979) · 2026Review
- Multiple sources of β2*-nicotinic acetylcholine receptor binding are differentially affected during tobacco smoking abstinence as revealed by Independent Component Analysis of [Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Caffeic acid phenethyl ester protects mice against nicotine-induced seizures by attenuating oxidative stress and inflammation.Research in pharmaceutical sciences · 2026Article
- Transcranial Magnetic Stimulation in Smoking Cessation: A Narrative Review of Neurobiological Mechanisms from Craving Modulation to Neural Circuit Restoration.Brain sciences · 2026Review
- CCK2R regulates METH-induced CPP acquisition within VTA-BLA-BNST circuit in male mice.Translational psychiatry · 2026Article
- Coolants, organic acids, flavourings and other additives that facilitate inhalation of tobacco and nicotine products: implications for regulation.Tobacco control · 2026Review
- Molecular Effect of Tobacco on Genetic, Epigenetic, and Metabolic Pathways During Cancer Progression.Cureus · 2026Review
- Advances in research on pharmacological mechanisms of anatabine: from nicotinic modulation to multitarget therapeutic potential.Experimental biology and medicine (Maywood, N.J.) · 2026Review
- Alpha-7 nicotinic acetylcholine receptor: targeting the interplay between inflammation, renin-angiotensin aldosterone system, and nervous system for the novel treatment of heart failure.Frontiers in pharmacology · 2026Review
- Association between smoking cessation and depressive symptoms according to cessation duration, pack-years, and tobacco product type: a nationwide cross-sectional study in Korea.Frontiers in public health · 2026Article
- Nicotiana tabacum: From a Beneficial Plant to Harmful Products-A Comprehensive Review of Smokeless Tobacco and Its Adverse Health Effects.TheScientificWorldJournal · 2026Review
- Smoking-Induced STC2Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Pharmacological Update and Safety Analysis of Medications for Smoking Cessation: Which Ones to Use?Current pharmaceutical design · 2026Review
- Awareness, Perceptions, and Use of Oral Nicotine Pouches Among Jazan University Students in Saudi Arabia: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2025Article
- Understanding varenicline function via key receptor and ligand interactions.Cell reports. Physical science · 2025Article
- Association of the -4719A/T Polymorphism in the RAD51 Gene with Demographic and Clinicopathological Features of Lung Cancer in Iraqi Patients.Asian Pacific journal of cancer prevention : APJCP · 2025Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Nicotine is a highly addictive drug found in tobacco that drives its continued use despite the harmful consequences. The initiation of nicotine abuse involves the mesolimbic dopamine system, which contributes to the rewarding sensory stimuli and associative learning processes in the beginning stages of addiction. Nicotine binds to neuronal nicotinic acetylcholine receptors (nAChRs), which come in a diverse collection of subtypes. The nAChRs that contain the α4 and β2 subunits, often in combination with the α6 subunit, are particularly important for nicotine's ability to increase midbrain dopamine neuron firing rates and phasic burst firing. Chronic nicotine exposure results in numerous neuroadaptations, including the upregulation of particular nAChR subtypes associated with long-term desensitization of the receptors. When nicotine is no longer present, for example during attempts to quit smoking, a withdrawal syndrome develops. The expression of physical withdrawal symptoms depends mainly on the α2, α3, α5, and β4 nicotinic subunits in the epithalamic habenular complex and its target regions. Thus, nicotine affects diverse neural systems and an array of nAChR subtypes to mediate the overall addiction process. This article is part of the special issue on 'Contemporary Advances in Nicotine Neuropharmacology'.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.