Evidence map›Paper›PMID 32738141›Full record

ArticleThe Journal of infectious diseases2020

Immunoserologic Detection and Diagnostic Relevance of Cross-Reactive Autoantibodies in Coronavirus Disease 2019 Patients.

María Teresa Schiaffino, Marisa Di Natale, Elena García-Martínez, Joaquín Navarro, José Luis Muñoz-Blanco, Pablo Demelo-Rodríguez, Paloma Sánchez-Mateos

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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  13. A scoping review of the pathophysiology of COVID-19.International journal of immunopathology and pharmacology
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

María Teresa SchiaffinoServicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Marisa Di NataleServicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Elena García-MartínezServicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Joaquín NavarroServicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
José Luis Muñoz-BlancoServicio de Neurología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Pablo Demelo-RodríguezServicio de Medicina Interna, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Paloma Sánchez-MateosServicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Hospital General Universitario Gregorio Marañón · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDuring the coronavirus disease 2019 (COVID-19) pandemic, we detected a new immunofluorescence (IF) pattern in serum autoantibody (autoAb) screening of laboratory-confirmed COVID-19 patients.

methodsThe IF pattern was composed of liver and gastric mucosa staining on rat kidney/liver/stomach sections.

resultsWe describe 12 patients positive for the cross-reactive antibody, compared with a negative group of 43 hospitalized COVID-19 patients, finding association with either neurologic or thrombotic complications. In sequential pre- and post-COVID-19 serum samples, we confirmed autoAb seroconversion.

conclusionsOur data indicate that autoAb screening in COVID-19 patients may be easily performed by IF and alert for autoreactive-mediated complications such as thrombotic or neurologic events.

Indexed as

BetacoronavirusAdultAgedAged, 80 and overAge FactorsAnimalsAutoantibodiesCase-Control StudiesCoronavirus InfectionsCOVID-19Cross ReactionsFemaleFerritinsFluorescent Antibody Technique, IndirectHumansMaleAutoantibodiesFerritinsautoantibodyautoimmunityCOVID-19immunofluorescencemolecular mimicry

Identifiers

PMID32738141
PMCPMC7454719
OpenAlexW3046900774

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.