Evidence map›Paper›PMID 32737940›Full record

ReviewChembiochem : a European journal of chemical biology2021

Chemical Approaches To Analyzing RNA Structure Transcriptome-Wide.

Whitney E England, Chely M Garfio, Robert C Spitale

Abstract readReview
In one paragraph

Review in Chembiochem : a European journal of chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. SHAPE to Probe RNA Structure and RNA-Protein Interactions In Vitro.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Whitney E EnglandDepartment of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92697, USA.
Chely M GarfioDepartment of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92697, USA.
Robert C SpitaleDepartment of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92697, USA.ORCID 0000-0002-3511-8098

Funding

Higher Precision Human and Mouse TranscriptomesUM1HG009443 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI MORTAZAVI, SEYED ALI, WOLD, BARBARA J · 2017 to 2021
$15.5M
NHGRI NIH HHS UM1 HG009443NIH HHS 5UM1HG009443-04
6 · The paper itself

Abstract

RNA molecules can fold into complex two- and three-dimensional shapes that are critical for their function. Chemical probes have long been utilized to interrogate RNA structure and are now considered invaluable resources in the goal of relating structure to function. Recently, the power of deep sequencing and careful chemical probe design have merged, permitting researchers to obtain a holistic understanding of how RNA structure can be utilized to control RNA biology transcriptome-wide. Within this review, we outline the recent advancements in chemical probe design for interrogating RNA structures inside cells and discuss the recent advances in our understanding of RNA biology through the lens of chemical probing.

Indexed as

TranscriptomeDNA AdductsDNA, ComplementaryMolecular ProbesNucleic Acid ConformationRNARNA, MessengerDNA AdductsDNA, ComplementaryMolecular ProbesRNARNA, MessengerLASERprobingRNASHAPEstructure

Identifiers

PMID32737940
PMCPMC8769560

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.