Evidence map›Paper›PMID 32737869›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2020

Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis.

Gabriella da Rosa Monte Machado, Denise Diedrich, Thaís Carine Ruaro, Aline Rigon Zimmer, Mário Lettieri Teixeira, Luís Flávio de Oliveira, Mickael Jean, Pierre Van de Weghe, Saulo Fernandes de Andrade, Simone Cristina Baggio Gnoatto and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 34 citations in OpenAlex.

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  5. Synthesis and crystal structures of (Acta crystallographica. Section E, Crystallographic communications · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Gabriella da Rosa Monte MachadoPostgraduate Program in Agricultural Microbiology and Environment, Federal University of Rio Grande do Sul, Sarmento Leite n° 500, Farroupilha, Porto Alegre, RS, 90050-170, Brazil. gabbirosam@gmail.ocom.ORCID http://orcid.org/0000-0003-1950-9731
Denise DiedrichPostgraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Avenue Ipiranga, n° 2752 - Azenha, Porto Alegre, RS, 90610-000, Brazil.
Thaís Carine RuaroPostgraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Avenue Ipiranga, n° 2752 - Azenha, Porto Alegre, RS, 90610-000, Brazil.
Aline Rigon ZimmerPostgraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Avenue Ipiranga, n° 2752 - Azenha, Porto Alegre, RS, 90610-000, Brazil.
Mário Lettieri TeixeiraPharmacology Laboratory, Federal Catarinense Institute, Highway SC 283 - Fragosos, Concórdia, SC, 89703-720, Brazil.
Luís Flávio de OliveiraCell Toxicology Research Laboratory, Federal University of Pampa, BR 472 - Km 585, Uruguaiana, RS, 97501-970, Brazil.
Mickael JeanNatural Products Syntheses and Medicinal Chemistry Laboratory, Rennes University 1, Street du Thabor, 35000, Rennes, France.
Pierre Van de WegheNatural Products Syntheses and Medicinal Chemistry Laboratory, Rennes University 1, Street du Thabor, 35000, Rennes, France.
Saulo Fernandes de AndradePostgraduate Program in Agricultural Microbiology and Environment, Federal University of Rio Grande do Sul, Sarmento Leite n° 500, Farroupilha, Porto Alegre, RS, 90050-170, Brazil.
Simone Cristina Baggio GnoattoPostgraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Avenue Ipiranga, n° 2752 - Azenha, Porto Alegre, RS, 90610-000, Brazil.
Alexandre Meneghello FuentefriaPostgraduate Program in Agricultural Microbiology and Environment, Federal University of Rio Grande do Sul, Sarmento Leite n° 500, Farroupilha, Porto Alegre, RS, 90050-170, Brazil.
Universidade Federal do Rio Grande do Sul · BRUniversité de Rennes · FRInstituto Federal Catarinense · BRUniversidade Federal do Pampa · BR

Funding

FAPERGS 16/2551-0000517-6
6 · The paper itself

Abstract

Fungal infections have emerged as a current serious global public health problem. The main problem involving these infections is the expansion of multidrug resistance. Therefore, the prospection of new compounds with efficacy antifungal becomes necessary. Thus, this study evaluated the antifungal profile and toxicological parameters of quinolines derivatives against Candida spp. and dermatophyte strains. As a result, a selective anti-dermatophytic action was demonstrated by compound 5 (geometric means (GM = 19.14 μg ml

Indexed as

AnimalsAntifungal AgentsArthrodermataceaeCandidaCell SurvivalChlorocebus aethiopsMicrobial Sensitivity TestsQuinolinesVero CellsAntifungal AgentsquinolineQuinolinesAntifungal potentialCandidaDermatophyteFungal resistanceQuinoline derivatives

Identifiers

PMID32737869
PMCPMC7394049
OpenAlexW3046598720

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.