Evidence map›Paper›PMID 32737656›Full record

ArticleInflammation2020

Electroacupuncture Attenuates Liver Inflammation in Nonalcoholic Fatty Liver Disease Rats.

Bingquan Ma, Peng Li, Hengyuan An, Zhiming Song

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bingquan MaDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. bqm@zzu.edu.cn.
Peng LiDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. fcclip1@zzu.edu.cn.ORCID http://orcid.org/0000-0002-9303-0094
Hengyuan AnDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Zhiming SongDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
First Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) has become a major health concern worldwide. The aim of this study was to investigate the effect and mechanism of electroacupuncture (EA) on nonalcoholic fatty liver disease (NAFLD) in rats induced by high-fat diet (HFD). A model of nonalcoholic fatty liver in rats induced by high fat was established. Rats in the control group were fed standard diet. The rats in model group and EA group were fed with HFD. From the fifth week, the rats in EA group were treated with EA ("FengLongXue," "YinLingQuanXue," "SanYinJiaoXue") for 2 weeks respectively. EA could significantly reduce serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum triglyceride (TG), serum cholesterol (TC), and serum cytokines, and improve liver histopathological changes in rats. EA also could regulate the levels of Sirt1/NF-κB pathway in rat liver. EA relieved liver injury in NAFLD rats, and its mechanism may be related to the regulation of Sirt1/NF-κB pathway in rats. This is the first report that electroacupuncture alleviates liver inflammatory reaction of nonalcoholic fatty liver by enhancing Sirt1 expression and inhibiting NLRP3/NF-kB signal pathway.

Indexed as

InflammationAlanine TransaminaseAnimalsAspartate AminotransferasesCholesterolCytokinesDiet, High-FatDisease ProgressionElectroacupunctureLipid MetabolismLipidsLiverMaleNon-alcoholic Fatty Liver DiseaseRatsRats, Sprague-DawleyAlanine TransaminaseAspartate AminotransferasesCholesterolCytokinesLipidsSirt1 protein, ratSirtuin 1TransaminasesTriglycerideselectroacupuncturehigh-fat diet (HFD)nonalcoholic fatty liver disease (NAFLD)Sirt1/NF-κB

Identifiers

PMID32737656
OpenAlexW3046815715

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.