Evidence map›Paper›PMID 32737637›Full record

Trial reportGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2021

Open versus minimally invasive total gastrectomy after neoadjuvant chemotherapy: results of a European randomized trial.

Nicole van der Wielen, Jennifer Straatman, Freek Daams, Riccardo Rosati, Paolo Parise, Jürgen Weitz, Christoph Reissfelder, Ismael Diez Del Val, Carlos Loureiro, Purificación Parada-González and 19 more

Erratum issuedOpen access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 84 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 4 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 4 syntheses or guidelines pooled it, 141 citations in OpenAlex.

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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors at 12 institutions in 6 countries.

Nicole van der WielenDepartment of Gastro-Intestinal Surgery, Amsterdam University Medical Center, Location VU University, De Boelelaan 1117, ZH 7F020, 1081 HV, Amsterdam, The Netherlands. ni.vanderwielen@amsterdamumc.nl.ORCID http://orcid.org/0000-0002-6166-0382
Jennifer StraatmanDepartment of Gastro-Intestinal Surgery, Amsterdam University Medical Center, Location VU University, De Boelelaan 1117, ZH 7F020, 1081 HV, Amsterdam, The Netherlands.
Freek DaamsDepartment of Gastro-Intestinal Surgery, Amsterdam University Medical Center, Location VU University, De Boelelaan 1117, ZH 7F020, 1081 HV, Amsterdam, The Netherlands.
Riccardo RosatiDepartment of Surgery, San Raffaele Hospital, Milan, Italy.
Paolo PariseDepartment of Surgery, San Raffaele Hospital, Milan, Italy.
Jürgen WeitzDepartment of Visceral-, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Dresden, Germany.
Christoph ReissfelderDepartment of Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Ismael Diez Del ValDepartment of Surgery, Hospital Universitario de Basurto, Bilbao, Spain.
Carlos LoureiroDepartment of Surgery, Hospital Universitario de Basurto, Bilbao, Spain.
Purificación Parada-GonzálezDepartment of Surgery, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain.
Elena Pintos-MartínezDepartment of Surgery, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain.
Francisco Mateo VallejoDepartment of Surgery, Hospital de Jerez, Jerez de la Frontera, Spain.
Carlos Medina AchiricaDepartment of Surgery, Hospital de Jerez, Jerez de la Frontera, Spain.
Andrés Sánchez-PernauteDepartment of Surgery, Hospital Clínico San Carlos, Madrid, Spain.
Adriana Ruano CamposDepartment of Surgery, Hospital Clínico San Carlos, Madrid, Spain.
Luigi BonavinaDepartment of Surgery, IRCCS Policlinico San Donato, Milan, Italy.
Emanuele L G AstiDepartment of Surgery, IRCCS Policlinico San Donato, Milan, Italy.
Alfredo Alonso PozaDepartment of Surgery, Hospital del Sureste, Madrid, Spain.
Carlos GilsanzDepartment of Surgery, Hospital del Sureste, Madrid, Spain.
Magnus NilssonDepartment of Surgery, Karolinska University Hospital, Stockholm, Sweden.
Mats LindbladDepartment of Surgery, Karolinska University Hospital, Stockholm, Sweden.
Suzanne S GisbertzDepartment of Gastro-intestinal Surgery, Amsterdam University Medical Center Location AMC, Amsterdam, The Netherlands.
Mark I van Berge HenegouwenDepartment of Gastro-intestinal Surgery, Amsterdam University Medical Center Location AMC, Amsterdam, The Netherlands.
Uberto Fumagalli RomarioDepartment of Surgery, ASST Spedali Civili, Brescia, Italy.
Stefano De PascaleDepartment of Surgery, ASST Spedali Civili, Brescia, Italy.
Khurshid AkhtarDepartment of Surgery, Salford Royal NHS Foundation Trust, Manchester, UK.
H Jaap BonjerDepartment of Gastro-Intestinal Surgery, Amsterdam University Medical Center, Location VU University, De Boelelaan 1117, ZH 7F020, 1081 HV, Amsterdam, The Netherlands.
Miguel A CuestaDepartment of Gastro-Intestinal Surgery, Amsterdam University Medical Center, Location VU University, De Boelelaan 1117, ZH 7F020, 1081 HV, Amsterdam, The Netherlands.
Donald L van der PeetDepartment of Gastro-Intestinal Surgery, Amsterdam University Medical Center, Location VU University, De Boelelaan 1117, ZH 7F020, 1081 HV, Amsterdam, The Netherlands.
Amsterdam University Medical Centers · NLAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITComplejo Hospitalario Universitario de Santiago · ESHospital Clínico San Carlos · ESHospital de Basurto · ESHospital Jerez Puerta del Sur · ESHospital Universitario del Sureste · ESIRCCS Policlinico San Donato · ITKarolinska University Hospital · SEHeidelberg University · DESalford Royal NHS Foundation Trust · GBUniversity Hospital Carl Gustav Carus · DE

Funding

Fonds NutsOhra 1303-035
6 · The paper itself

Abstract

backgroundSurgical resection with adequate lymphadenectomy is regarded the only curative option for gastric cancer. Regarding minimally invasive techniques, mainly Asian studies showed comparable oncological and short-term postoperative outcomes. The incidence of gastric cancer is lower in the Western population and patients often present with more advanced stages of disease. Therefore, the reproducibility of these Asian results in the Western population remains to be investigated.

methodsA randomized trial was performed in thirteen hospitals in Europe. Patients with an indication for total gastrectomy who received neoadjuvant chemotherapy were eligible for inclusion and randomized between open total gastrectomy (OTG) or minimally invasive total gastrectomy (MITG). Primary outcome was oncological safety, measured as the number of resected lymph nodes and radicality. Secondary outcomes were postoperative complications, recovery and 1-year survival.

resultsBetween January 2015 and June 2018, 96 patients were included in this trial. Forty-nine patients were randomized to OTG and 47 to MITG. The mean number of resected lymph nodes was 43.4 ± 17.3 in OTG and 41.7 ± 16.1 in MITG (p = 0.612). Forty-eight patients in the OTG group had a R0 resection and 44 patients in the MITG group (p = 0.617). One-year survival was 90.4% in OTG and 85.5% in MITG (p = 0.701). No significant differences were found regarding postoperative complications and recovery.

conclusionThese findings provide evidence that MITG after neoadjuvant therapy is not inferior regarding oncological quality of resection in comparison to OTG in Western patients with resectable gastric cancer. In addition, no differences in postoperative complications and recovery were seen.

Indexed as

Asian PeopleChemotherapy, AdjuvantEuropeFemaleGastrectomyHumansLymph Node ExcisionMaleMiddle AgedMinimally Invasive Surgical ProceduresNeoadjuvant TherapyPostoperative ComplicationsReproducibility of ResultsStomach NeoplasmsTreatment OutcomeWhite PeopleMinimally invasive total gastrectomyNeoadjuvant chemotherapy

Identifiers

PMID32737637
PMCPMC7790799
OpenAlexW3046380630

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.