Evidence map›Paper›PMID 32737612›Full record

ArticleEuropean journal of nutrition2021

Serum magnesium concentration and incident cognitive impairment: the reasons for geographic and racial differences in stroke study.

Cheng Chen, Pengcheng Xun, Frederick Unverzagt, Leslie A McClure, Marguerite Ryan Irvin, Suzanne Judd, Mary Cushman, Ka He

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PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The effects of magnesium L-threonate (MagteinFrontiers in nutrition · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cheng ChenDepartment of Obstetrics and Gynecology and Department of Epidemiology, Columbia University Irving Medical Center, New York, NY, USA.
Pengcheng XunDepartment of Epidemiology and Biostatistics, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA.
Frederick UnverzagtDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Leslie A McClureDepartment of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA, USA.
Marguerite Ryan IrvinDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Suzanne JuddDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Mary CushmanDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT, USA.
Ka HeDepartment of Obstetrics and Gynecology and Department of Epidemiology, Columbia University Irving Medical Center, New York, NY, USA. kk3399@cumc.columbia.edu.ORCID http://orcid.org/0000-0003-1451-3889

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Trace mineral levels, the trajectory of cognitive decline and telomere attritionRF1AG056111 · NIA · TRUSTEES OF INDIANA UNIVERSITY · PI KAHE, KA · 2017 to 2017
$3.1M
ACL HHS U01DP006302NIA NIH HHS RF1 AG056111NIH HHS R01AG056111NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

purposeTo examine the prospective association between serum Mg level and the incidence of cognitive impairment.

methodsA random sub-cohort (n = 2063) from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort was included in this study. Baseline serum Mg concentration was measured using inductively coupled plasma mass spectrometry. According to the current reference interval of serum magnesium (0.75-0.95 mmol/L), we classified participants below the interval as Level 1 and used it as the referent. The rest of the study population were equally divided into three groups, named Level 2 to 4. Incident cognitive impairment was identified using the Six-Item Screener. Multivariable-adjusted odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using logistic regression models.

resultsAfter adjustment for potential confounders, an inverse threshold association between serum Mg level and incident cognitive impairment was observed. Compared to those with hypomagnesemia (Level 1: < 0.75 mmol/L), the relative odds of incident cognitive impairment was reduced by 41% in the second level [OR (95% CI) = 0.59 (0.37, 0.94)]; higher serum Mg level did not provide further benefits [Level 3 and 4 versus Level 1: OR (95% CI) = 0.54 (0.34, 0.88) and 0.59 (0.36, 0.96), P for linear trend = 0.08].

conclusionsFindings from this prospective study suggest that sufficient Mg status within the normal range may be beneficial to cognitive health in the US general population.

Indexed as

Cognition DisordersCognitive DysfunctionStrokeHumansIncidenceMagnesiumProspective StudiesRace FactorsRisk FactorsMagnesium

Identifiers

PMID32737612
PMCPMC7854858

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.